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Merck
CN

T3397

泰乐菌素 溶液

solution, suitable for cell culture, BioReagent

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关于此项目

化学文摘社编号:
74610-55-2
UNSPSC Code:
12352207
PubChem Substance ID:
329826751
NACRES:
NA.76
MDL number:
MFCD07783824

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产品名称

泰乐菌素 溶液, 8 mg/mL in 0.9% NaCl, 0.1 μm filtered, BioReagent, suitable for cell culture

Quality Level

200

SMILES string

O[C@H]([C@@H](O)C(O)=O)C(O)=O.CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@@H](O)[C@H](C)O3)[C@@H]([C@H]2O)N(C)C)[C@@H](CC=O)C[C@@H](C)C(=O)\C=C\C(C)=C\[C@@H]1CO[C@@H]4O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]4OC

InChI key

ICVKYYINQHWDLM-KBEWXLTPSA-N

InChI

1S/C46H77NO17.C4H6O6/c1-13-33-30(22-58-45-42(57-12)41(56-11)37(52)26(5)60-45)18-23(2)14-15-31(49)24(3)19-29(16-17-48)39(25(4)32(50)20-34(51)62-33)64-44-38(53)36(47(9)10)40(27(6)61-44)63-35-21-46(8,55)43(54)28(7)59-35;5-1(3(7)8)2(6)4(9)10/h14-15,17-18,24-30,32-33,35-45,50,52-55H,13,16,19-22H2,1-12H3;1-2,5-6H,(H,7,8)(H,9,10)/b15-14+,23-18+;/t24-,25+,26-,27-,28+,29+,30-,32-,33-,35+,36-,37-,38-,39-,40-,41-,42-,43+,44+,45-,46-;1-,2-/m11/s1

sterility

0.1 μm filtered

product line

BioReagent

form

solution

concentration

8 mg/mL in 0.9% NaCl

technique(s)

cell culture | mammalian: suitable

impurities

endotoxin, tested

color

colorless to yellow

antibiotic activity spectrum

Gram-positive bacteria, mycoplasma

mode of action

protein synthesis | interferes

storage temp.

2-8°C

相关类别

General description

Chemical structure: macrolide
Tylosin is a macrolide antibiotic, which comprises of a 16-member lactone ring. This solution is recommended for use at 1 mL/L.

Application

Tylosin solution has been used as an antimicrobial agent in antibiotic susceptibility minimal inhibitory concentration(MIC) of E. coli and S. aureus isolates. It has also been used as a component of Dulbecco′s modified Eagle′s (DMEM) medium for self-inactivating lentivirus production and skin fibroblast cultivation.

Biochem/physiol Actions

Tylosin inhibits bacterial protein synthesis by binding to the large subunit 50S. It is effective against Gram-positive bacteria and mycoplasma and is used in veterinary medicine. It has been used to study implant site abscess prevention in cattle and Mycoplasma gallisepticum and Mycoplasma meleagridis infections.

Packaging

20ML

Preparation Note

Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and keep upright to prevent leakage.
This product was formulated to contain 8 mg/ml tylosin in 0.9% sodium chloride.

Other Notes

Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage.

存储类别

10 - Combustible liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

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分析证书(COA)

Lot/Batch Number
0000496995
0000496995
0000385355
0000385355
0000261783

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Gonzalez P, et al.
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EVALUATION OF THE EFFECT OF TYLOSIN (MACROLIDE ANTIBIOTICS) ON MURINE TOXOPLASMOSIS
Asgari Q, et al.
International Journal of Pharmaceutical Sciences and Research, 9(7), 2891-2896 (2018)
Tools for characterizing bacterial protein synthesis inhibitors
Orelle C, et al.
Antimicrobial Agents and Chemotherapy, 57(12), 5994-6004 (2013)
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In order to be more practical on evaluating the response of soil microbial communities to Cu contamination, we compared the microbial activity and selection for the microbial tolerance after a high level Cu exposure in single and corresponding repeated addition.
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