T3434
酪磷蛋白 AG 490
solid
别名:
2-氰基-3-（3,4-二羟基苯基）-N-（苄基）-2-丙烯酰胺, 2-氰基-3-（3,4-二羟基苯基）-N-（苯甲基）-2-丙烯酰胺
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关于此项目
经验公式（希尔记法）:
C17H14N2O3
化学文摘社编号:
分子量:
294.30
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
产品名称
酪磷蛋白 AG 490, solid
InChI
1S/C17H14N2O3/c18-10-14(8-13-6-7-15(20)16(21)9-13)17(22)19-11-12-4-2-1-3-5-12/h1-9,20-21H,11H2,(H,19,22)/b14-8+
SMILES string
Oc1ccc(cc1O)\C=C(/C#N)C(=O)NCc2ccccc2
InChI key
TUCIOBMMDDOEMM-RIYZIHGNSA-N
biological source
synthetic (organic)
assay
≥98% (HPLC)
form
solid
color
yellow
solubility
DMSO: soluble 10 mg/ml, clear, yellow
ethanol: 5 mg/mL
H2O: insoluble
storage temp.
−20°C
Quality Level
Gene Information
human ... EGFR(1956), ERBB2(2064), IL2(3558), JAK2(3717)
相关类别
Application
Tyrphostin AG 已被用于阻断 IL-6 细胞因子信号传导，研究其对神经胶质细胞反应性的影响 5 。AG 490 也被用作人脐静脉内皮细胞的 JAK2 抑制剂 6 。
Biochem/physiol Actions
Jak-2 蛋白酪氨酸激酶 (PTK) 抑制剂。抑制白细胞介素 2 (IL-2) 驱动的有丝分裂并触发 Sezary 综合征（一种皮肤 T 细胞淋巴瘤的白血病变体）的肿瘤细胞凋亡。
Disclaimer
光敏
Features and Benefits
该化合物是激酶磷酸酶生物学研究的特色产品。 点击此处 ，发现更多特色激酶磷酸酶生物学产品。在 sigma.com/discover-bsm了解更多关于其他研究领域的生物活性小分子。
Preparation Note
Tyrphostin AG 490 溶于乙醇，浓度为 5 mg/mL，不溶于水。也可溶于 10 mg/mL 的 DMSO 中，并产生澄清的黄色溶液。
存储类别
11 - Combustible Solids
wgk
WGK 3
Mengqi Jiang et al.
Oxidative medicine and cellular longevity, 2021, 7385160-7385160 (2021-08-31)
Obesity is considered as a risk factor of osteoarthritis (OA), but the precise relationship is still poorly understood. Leptin, one of the most relevant factors secreted by adipose tissues, plays an important role in the pathogenesis of OA. Our aim
J Abe et al.
The Journal of biological chemistry, 274(30), 21003-21010 (1999-07-20)
Reactive oxygen species (ROS) activate Ras and the extracellular signal-regulated kinase (ERK) cascade. Because JAK2 is a critical mediator for Ras/Raf/ERK activation by several hormones, we examined the role of JAK2 in ROS signal events. H(2)O(2) stimulated JAK2 activity in
K W Eriksen et al.
Leukemia, 15(5), 787-793 (2001-05-23)
Interleukin-2 (IL-2) is a growth factor which upon binding to high-affinity receptors (IL-2Ralphabetagamma) triggers mitogenesis in T cells. IL-2Ralpha expression is restricted to T cells which have recently encountered antigen, and in healthy individuals the majority (>95%) of peripheral T
Tao Geng et al.
Gene, 595(1), 69-76 (2016-10-04)
Innate immunity was critical in insects defensive system and able to be induced by Janus kinase/signal transducer and activator of transcription cascade transduction (JAK/STAT) signaling pathway. Currently, it had been identified many JAK/STAT signaling pathway-related genes in silkworm, but little
Wai Hoe Lau et al.
Oncotarget, 8(20), 32884-32904 (2017-04-22)
Activation of TLR3 stimulates cancer cell apoptosis and triggers secretion of inflammatory cytokines. PolyI:C, a TLR3 agonist, activates immune cells and regresses metastatic lung cancer in vivo. Although polyI:C reportedly kills lung carcinomas, the mechanism remains elusive. Here, we demonstrated
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