T3452
Toloxatone
≥98% (HPLC), solid
别名:
5-(hydroxymethyl)-3-(3-methylphenyl)-2-oxazolidinone, Humoryl
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关于此项目
经验公式（希尔记法）:
C11H13NO3
化学文摘社编号:
分子量:
207.23
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12161501
EC Number:
249-522-2
MDL number:
Quality Level
assay
≥98% (HPLC)
form
solid
storage condition
desiccated
solubility
DMSO: >10 mg/mL
storage temp.
2-8°C
SMILES string
Cc1cccc(c1)N2CC(CO)OC2=O
InChI
1S/C11H13NO3/c1-8-3-2-4-9(5-8)12-6-10(7-13)15-11(12)14/h2-5,10,13H,6-7H2,1H3
InChI key
MXUNKHLAEDCYJL-UHFFFAOYSA-N
相关类别
Biochem/physiol Actions
Toloxatone is a reversible monoamine oxidase A inhibitor (MAOI) and antidepressant.
Toloxatone is a reversible monoamine oxidase A inhibitor (MAOI) and antidepressant. Toloxatone belongs to the aryloxazolidinones, a relatively new class of reversible monoamine oxidase A inhibitors (MAOI). Studies show that derivatives such as 3-aryloxazolidin-2-one (oxazolidinones), which are regularly used to treat gram positive infections, represent a new class of reversible as well as irreversible inhibitors for MAO-A and MAO-B enzymes that are able to inhibit protein synthesis and also used for neurodegenerative-type pathologies.
Preparation Note
Toloxatone is soluble in DMSO at a concentration that is greater than 10 mg/ml.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Jeong Hyun Heo et al.
Scientific reports, 10(1), 21695-21695 (2020-12-12)
Cholinesterase (ChE) and monoamine oxidase (MAO) inhibitors have been attracted as candidate treatments for Alzheimer's disease (AD). Fifteen khellactone-type coumarins from the roots of Peucedanum japonicum Thunberg were tested for acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and MAO inhibitory activities. Compound 3'-angeloyl-4'-(2-methylbutyryl)khellactone
Robert Skibiński et al.
Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society, 26(4), 467-480 (2018-05-31)
Forced degradation of toloxatone in solutions under basic, acidic, neutral, photo UV-VIS, photo UVC and oxidative stress conditions was investigated and structural elucidation of its degradation products was performed with the use of UHPLC system coupled ESI-Q-TOF mass spectrometer. Eight
M L Kaltenbach et al.
Alcoholism, clinical and experimental research, 23(5), 885-890 (1999-06-17)
The pharmacokinetics of toloxatone and ethanol were determined in plasma and cerebrospinal fluid of conscious rabbits. According to a cross-over design, rabbits (n = 5) randomly received on three separate occasions either toloxatone (5 mg/kg), ethanol (1 g/kg), or toloxatone
Seung Cheol Baek et al.
Bioorganic chemistry, 83, 317-325 (2018-11-06)
Three flavanones and two flavones were isolated from the leaves of Prunus padus var. seoulensis by the activity-guided screening for new monoamine oxidase (MAO) inhibitors. Among the compounds isolated, rhamnocitrin (5) was found to potently and selectively inhibit human MAO-A
Geum Seok Jeong et al.
Molecules (Basel, Switzerland), 25(17) (2020-08-30)
Eight compounds were isolated from the roots of Glycyrrhiza uralensis and tested for cholinesterase (ChE) and monoamine oxidase (MAO) inhibitory activities. The coumarin glycyrol (GC) effectively inhibited butyrylcholinesterase (BChE) and acetylcholinesterase (AChE) with IC50 values of 7.22 and 14.77 µM
商品
Serotonin is stored in cells and metabolized by MAO, influencing CNS, GI, and platelet functions.
血清素（5-羟色胺）主要存在于三种主要细胞类型中：i）中杻神经系统（CNS）和肠肌间神经丛中的血清素能神经元，ii）胃肠道粘膜中的肠嗜铬细胞，和iii）血小板。血清素的代谢主要通过外部线粒体膜酶单胺氧化酶（MAO）进行，它以两种分子亚型存在，分别称为MAO-A和MAO-B。
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| T3452-50MG | 04061832931555 |
| T3452-10MG | 04061832931548 |
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