T3830
曲西瑞宾 水合物
≥97% (HPLC)
别名:
API-2, Akt/PKB信号传导抑制剂2, NSC 154020, TCN, VD-0002, 抑制剂 V
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选择尺寸
关于此项目
经验公式（希尔记法）:
C13H16N6O4 · xH2O
化学文摘社编号:
分子量:
320.30 (anhydrous basis)
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
产品名称
曲西瑞宾 水合物, ≥97% (HPLC)
InChI key
SPGRLWCWHWRPHX-DOKXERMVSA-N
SMILES string
O.Cn1nc(N)c2cn([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)c4ncnc1c24
InChI
1S/C13H16N6O4.H2O/c1-18-11-7-5(10(14)17-18)2-19(12(7)16-4-15-11)13-9(22)8(21)6(3-20)23-13;/h2,4,6,8-9,13,20-22H,3H2,1H3,(H2,14,17);1H2/t6-,8-,9-,13-;/m1./s1
assay
≥97% (HPLC)
form
powder
color
tan
solubility
DMSO: >10 mg/mL
storage temp.
2-8°C
Quality Level
Gene Information
human ... AKT1(207)
mouse ... AKT1(11651)
rat ... AKT1(24185)
相关类别
Application
曲西立滨水合物已被用于研究二乙基二硫代氨基甲酸酯（DDC）对肝星状细胞中基质金属蛋白酶-1（MMP-1）的作用1。它还被用于分析过表达瑞典突变APP（SweAPP N2a细胞）的N2a细胞中(-)-表没食子儿茶素-3-没食子酸酯（EGCG）的ADAM 10激活作用2。
Biochem/physiol Actions
曲西瑞宾是一种高度选择性的Akt/PKB抑制剂，可选择性抑制Akt1/2/3的细胞磷酸化/激活。
Preparation Note
曲西立滨水合物溶于DMSO，溶解浓度大于10 mg/ml。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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