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About This Item
经验公式（希尔记法）:
C16H14N2
CAS Number:
分子量:
234.30
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
方案
≥98%
溶解性
0.1 M HCl: soluble <1 mg/mL
ethanol: soluble 10 mg/mL
methylene chloride: soluble 10 mg/mL
0.1 M NaOH: insoluble
2-hydroxypropyl-β-cyclodextrin: insoluble
H2O: insoluble
储存温度
−20°C
SMILES字符串
Cc1cc2ncc(nc2cc1C)-c3ccccc3
基因信息
human ... EGFR(1956), FLT3(2322), PDGFRB(5159), SRC(6714)
mouse ... Pdgfrb(18596)
应用
Tyrphostin AG 1295 has been used as an Flt3 inhibitor in NA10 and ND13 progenitor cell lines2. Studies using AG 1295 have reported that it can reduce cell division and DNA synthesis induced by nicotine in human aortic vascular smooth muscle cells3.
Tyrphostin AG 1295 is soluble in methylene chloride at 10 mg/ml, in ethanol at 10 mg/ml and in 0.1 N HCl at less than 1 mg/ml. It is however, insoluble in water, 0.1 N sodium hydroxide, and 2-hydroxypropyl-β-cyclodextrin.
生化/生理作用
Selective inhibitor of tyrosine kinase in platelet-derived growth factor (PDGF) receptor.
Studies in mouse osteoblastic MC3T3-E1 cells have reported that AG 1295 can enhance matrix mineralization and osteoblast differentiation by inhibiting PDGFR-β signaling4.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
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