T3932
Tyrphostin AG 1295
≥98%
别名:
6,7-Dimethyl-2-phenylquinoxaline
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关于此项目
经验公式（希尔记法）:
C16H14N2
化学文摘社编号:
分子量:
234.30
UNSPSC Code:
12352200
PubChem Substance ID:
MDL number:
assay
≥98%
solubility
0.1 M HCl: soluble <1 mg/mL, ethanol: soluble 10 mg/mL, methylene chloride: soluble 10 mg/mL, 0.1 M NaOH: insoluble, 2-hydroxypropyl-β-cyclodextrin: insoluble, H2O: insoluble
storage temp.
−20°C
SMILES string
Cc1cc2ncc(nc2cc1C)-c3ccccc3
Gene Information
human ... EGFR(1956), FLT3(2322), PDGFRB(5159), SRC(6714)
mouse ... Pdgfrb(18596)
Application
Tyrphostin AG 1295 has been used as an Flt3 inhibitor in NA10 and ND13 progenitor cell lines2. Studies using AG 1295 have reported that it can reduce cell division and DNA synthesis induced by nicotine in human aortic vascular smooth muscle cells3.
Tyrphostin AG 1295 is soluble in methylene chloride at 10 mg/ml, in ethanol at 10 mg/ml and in 0.1 N HCl at less than 1 mg/ml. It is however, insoluble in water, 0.1 N sodium hydroxide, and 2-hydroxypropyl-β-cyclodextrin.
Biochem/physiol Actions
Selective inhibitor of tyrosine kinase in platelet-derived growth factor (PDGF) receptor.
Studies in mouse osteoblastic MC3T3-E1 cells have reported that AG 1295 can enhance matrix mineralization and osteoblast differentiation by inhibiting PDGFR-β signaling4.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)