T3932
Tyrphostin AG 1295
≥98%
别名:
6,7-Dimethyl-2-phenylquinoxaline
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关于此项目
经验公式（希尔记法）:
C16H14N2
化学文摘社编号:
分子量:
234.30
UNSPSC Code:
12352200
PubChem Substance ID:
MDL number:
SMILES string
Cc1cc2ncc(nc2cc1C)-c3ccccc3
assay
≥98%
solubility
0.1 M HCl: soluble <1 mg/mL, ethanol: soluble 10 mg/mL, methylene chloride: soluble 10 mg/mL, 0.1 M NaOH: insoluble, 2-hydroxypropyl-β-cyclodextrin: insoluble, H2O: insoluble
storage temp.
−20°C
Gene Information
human ... EGFR(1956), FLT3(2322), PDGFRB(5159), SRC(6714)
mouse ... Pdgfrb(18596)
Application
Tyrphostin AG 1295 has been used as an Flt3 inhibitor in NA10 and ND13 progenitor cell lines2. Studies using AG 1295 have reported that it can reduce cell division and DNA synthesis induced by nicotine in human aortic vascular smooth muscle cells3.
Tyrphostin AG 1295 is soluble in methylene chloride at 10 mg/ml, in ethanol at 10 mg/ml and in 0.1 N HCl at less than 1 mg/ml. It is however, insoluble in water, 0.1 N sodium hydroxide, and 2-hydroxypropyl-β-cyclodextrin.
Biochem/physiol Actions
Selective inhibitor of tyrosine kinase in platelet-derived growth factor (PDGF) receptor.
Studies in mouse osteoblastic MC3T3-E1 cells have reported that AG 1295 can enhance matrix mineralization and osteoblast differentiation by inhibiting PDGFR-β signaling4.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
M Kovalenko et al.
Cancer research, 54(23), 6106-6114 (1994-12-01)
A novel class of tyrosine kinase blockers represented by the tyrphostins AG1295 and AG1296 is described. These compounds inhibit selectively the platelet-derived growth factor (PDGF) receptor kinase and the PDGF-dependent DNA synthesis in Swiss 3T3 cells and in porcine aorta
Ivo A Pestana et al.
Journal of cellular biochemistry, 96(5), 986-995 (2005-09-09)
Cigarette smoking is implicated in the formation of occlusive vascular diseases. Nicotine's role in this process is incompletely understood. Nicotine's effect on human aortic vascular smooth muscle cells (HaVSMC) and the role of the nicotinic receptor (nAChR), platelet-derived growth factor
Y Y Zhang et al.
Bioscience trends, 6(3), 130-135 (2012-08-15)
Previous studies have conflicting views on the effect of platelet-derived growth factor (PDGF)/PDGF receptor (PDGFR) signaling on osteogenesis. The current study investigated the effect of PDGF receptor-beta (PDGFR-β) inhibition by AG-1295 on the osteogenic differentiation of the mouse pre-osteoblastic cell
Lars Palmqvist et al.
Blood, 108(3), 1030-1036 (2006-07-25)
In leukemogenesis, several genetic changes conferring a proliferative and/or survival advantage to hematopoietic progenitor cells in addition to a block in differentiation are required. Here, we demonstrate that overexpression of the wild-type (wt) Flt3 receptor tyrosine kinase collaborates with NUP98-HOX
Junichi Kasuya et al.
Journal of tissue engineering and regenerative medicine, 9(3), 247-256 (2012-10-23)
In liver sinusoids, hepatic stellate cells (HSCs) locate the outer surface of microvessels to form a functional unit with endothelia and hepatocytes. To reconstruct functional liver tissue in vitro, formation of the HSC-incorporated sinusoidal structure is essential. We previously demonstrated
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