Name: Tobramycin
Brand: SIGMA

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About This Item

经验公式（希尔记法）:

C₁₈H₃₇N₅O₉

CAS Number:

32986-56-4

分子量:

467.51

Beilstein:

1357507

EC 号:

251-322-5

MDL编号:

MFCD00077885

UNSPSC代码:

51281626

PubChem化学物质编号:

24900188

NACRES:

NA.85

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生物来源

Streptomyces tenebrarius

表单

powder

储存条件

(Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.)

浓度

≥900 μg/mg (anhydrous)

颜色

white to off-white

抗生素抗菌谱

Gram-negative bacteria

作用机制

protein synthesis | interferes

储存温度

2-8°C

SMILES字符串

NC[C@H]1O[C@H](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@@H](N)[C@H]3O)[C@H]2O)[C@H](N)C[C@@H]1O

InChI

1S/C18H37N5O9/c19-3-9-8(25)2-7(22)17(29-9)31-15-5(20)1-6(21)16(14(15)28)32-18-13(27)11(23)12(26)10(4-24)30-18/h5-18,24-28H,1-4,19-23H2/t5-,6+,7+,8-,9+,10+,11+,12+,13+,14-,15+,16-,17+,18+/m0/s1

InChI key

NLVFBUXFDBBNBW-SNGYORCQSA-N

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一般描述

Chemical structure: aminoglycoside

Tobramycin is an aminoglycoside, broad-spectrum antibiotic produced by Streptomyces tenebrarius. It is effective against gram-negative bacteria, especially the Pseudomonas species.

应用

Tobramycin has been used:

to study the effect of tobramycin on bacteriophage infected biofilms
to study the effects of antibiotics on Pseudomonas aeruginosa strain
as a comparator antibiotic

生化/生理作用

Tobramycin binds irreversibly to one of two aminoglycoside binding sites on the 30S ribosomal subunit, inhibiting bacterial protein synthesis. Tobramycin may also destabilize bacterial membranes by binding to 16S rRNA (ribosomal RNA). It inhibits translocation and elicits miscoding.
Tobramycin is used to treat Pseudomonas aeruginosa lung infections and is used in combination with other antibiotics to treat urinary tract infections, gynecologic infections, peritonitis, endocarditis, pneumonia, sepsis, respiratory infections, osteomyelitis, and other soft-tissue infections. It is a potential therapy for sinus infections.

Tobramycin is an aminoglycoside.
Mode of Action: Binds to 70S ribosomal subunit; inhibits translocation; elicits miscoding.
Spectrum of Activity: Gram negative bacteria. Not effective against Enterococci.