T4143
氨苯蝶啶
≥99%
别名:
2,4,7-Triamino-6-phenylpteridine, 6-Phenyl-2,4,7-pteridinetriamine
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关于此项目
经验公式（希尔记法）:
C12H11N7
化学文摘社编号:
分子量:
253.26
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
206-904-3
MDL number:
InChI key
FNYLWPVRPXGIIP-UHFFFAOYSA-N
InChI
1S/C12H11N7/c13-9-7(6-4-2-1-3-5-6)16-8-10(14)18-12(15)19-11(8)17-9/h1-5H,(H6,13,14,15,17,18,19)
SMILES string
Nc1nc(N)c2nc(-c3ccccc3)c(N)nc2n1
assay
≥99%
solubility
45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: soluble 1.2 mg/mL, DMSO: soluble 5.4 mg/mL, H2O: insoluble
originator
Wellspring
Quality Level
Gene Information
human ... SCNN1A(6337), SCNN1B(6338), SCNN1G(6340)
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Application
Triamterene has been used to study its effects on urokinase receptor (uPAR) induction in podocytes under in vitro conditions2. Triamterene has also been identified as an activator compound from a LOPAC library screen using a fluorogenic α-glucosidase assay3.
Biochem/physiol Actions
Weak diuretic with potassium sparing properties; blocks Na+ reuptake in the kidneys.
Features and Benefits
This compound was developed by Wellspring. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
Preparation Note
200 mg of triamterene is soluble in 4 ml of warm formic acid and yields a clear, yellow-green solution. Triamterene is also soluble in DMSO (5.4 mg/ml), and in 45% (w/v) aqueous 2-hydroxypropyl-β-cyclodextrin (1.2 mg/ml). However, it is insoluble in water.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
法规信息
新产品
此项目有
Balraj S Heran et al.
The Cochrane database of systematic reviews, (1)(1), CD008167-CD008167 (2010-01-22)
Potassium-sparing diuretics, which block the epithelial sodium channel (ENaC), are widely prescribed for hypertension as a second-line drug in patients taking other diuretics (e.g. thiazide diuretics) and much less commonly prescribed as monotherapy. Therefore, it is essential to determine the
Yiqun Wu et al.
Clinical drug investigation, 31(11), 769-777 (2011-06-16)
A fixed-dose combination (FDC) of four compounds, hydrochlorothiazide 12.5 mg, triamterene 12.5 mg, dihydralazine 12.5 mg and reserpine 0.1 mg (HTDR), is widely used as an antihypertensive treatment in China. Although HTDR has been used in China for more than
Ali Asghar Ensafi et al.
Analytical sciences : the international journal of the Japan Society for Analytical Chemistry, 24(11), 1449-1454 (2008-11-11)
A square-wave voltammetric procedure for the electroanalytical determination of losartan and triamterene in Britton-Robinson buffer (pH 3.0, 0.1 mol L(-1)) as a supporting electrolyte containing 30 ng mL(-1) of copper ions was developed. Opposite to the case of triamterene, losartan
Zhuomin Zhang et al.
The Analyst, 133(9), 1187-1194 (2008-08-19)
In competition sports, a diuretic is a substance widely prohibited by the World Anti-Doping Agency (WADA). In this paper, a sensitive, rapid and convenient analytical method for the determination of acidic [furosemide (FUROS) and bumetanide (BUMET)] and basic [triamterene (TRIAM)]
Reuben Domike et al.
International journal of pharmaceutics, 391(1-2), 13-20 (2010-02-17)
The use of a light induced fluorescence (LIF) instrument to estimate the total content of fluorescent active pharmaceutical ingredient in a tablet from surface sampling was demonstrated. Different LIF sampling strategies were compared to a total tablet ultraviolet (UV) absorbance
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