T4143
氨苯蝶啶
≥99%
别名:
2,4,7-Triamino-6-phenylpteridine, 6-Phenyl-2,4,7-pteridinetriamine
质量水平
方案
≥99%
溶解性
45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: soluble 1.2 mg/mL
DMSO: soluble 5.4 mg/mL
H2O: insoluble
创始人
Wellspring
SMILES字符串
Nc1nc(N)c2nc(-c3ccccc3)c(N)nc2n1
InChI
1S/C12H11N7/c13-9-7(6-4-2-1-3-5-6)16-8-10(14)18-12(15)19-11(8)17-9/h1-5H,(H6,13,14,15,17,18,19)
InChI key
FNYLWPVRPXGIIP-UHFFFAOYSA-N
基因信息
human ... SCNN1A(6337), SCNN1B(6338), SCNN1G(6340)
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应用
Triamterene has been used to study its effects on urokinase receptor (uPAR) induction in podocytes under in vitro conditions2. Triamterene has also been identified as an activator compound from a LOPAC library screen using a fluorogenic α-glucosidase assay3.
生化/生理作用
Weak diuretic with potassium sparing properties; blocks Na+ reuptake in the kidneys.
特点和优势
This compound was developed by Wellspring. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
制备说明
200 mg of triamterene is soluble in 4 ml of warm formic acid and yields a clear, yellow-green solution. Triamterene is also soluble in DMSO (5.4 mg/ml), and in 45% (w/v) aqueous 2-hydroxypropyl-β-cyclodextrin (1.2 mg/ml). However, it is insoluble in water.
警示用语：
Warning
危险分类
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
法规信息
新产品
此项目有
Mehrdad Hamidi et al.
Regulatory toxicology and pharmacology : RTP, 59(1), 149-156 (2011-01-05)
In this study, an open, double-blind, randomized, two-period, two-group crossover design was conducted in 14 healthy volunteers to study the bioequivalence of a fixed-dose generic product. After administration of test or reference products to each volunteer, both active ingredients were
Indoleamine 2,3-dioxygenase-expressing mature human monocyte-derived dendritic cells expand potent autologous regulatory T cells: consideration of triamterene to treat lupus.
Richard E Kast et al.
Medical hypotheses, 74(5), 957-957 (2010-02-02)
Balraj S Heran et al.
The Cochrane database of systematic reviews, 11, CD008167-CD008167 (2012-11-16)
Potassium-sparing diuretics, which block the epithelial sodium channel (ENaC), are widely prescribed for hypertension as a second-line drug in patients taking other diuretics (e.g. thiazide diuretics) and much less commonly prescribed as monotherapy. Therefore, it is essential to determine the
Ki-Woong Jeong et al.
Biochemistry, 50(22), 4843-4854 (2011-05-07)
Vascular endothelial growth factor (VEGF), which has neurotrophic and neuroprotective effects in addition to its major role in angiogenesis, interacts with Aβ and accumulates in the senile plaques of Alzheimer's disease (AD) patients' brains. It is known that Aβ binds
A Kato et al.
The American journal of physiology, 276(1 Pt 2), F62-F71 (1999-01-14)
Infusing urea into low-protein-fed mammals increases urine concentration within 5-10 min. To determine which urea transporter may be responsible, we measured urea transport in perfused IMCD3 segments [inner medullary collecting duct (IMCD) segments from the deepest third of the IMCD]
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