Application
Human Testosterone Receptor was used to study the role of androgens in producing cardiac hypertrophy on cardiac myocytes by direct, receptor-specific mechanisms.
Biochem/physiol Actions
Human Testosterone Receptor also referred to as androgen receptor (AR) belongs to nuclear receptor family and is activated in the presence of androgenic hormones testosterone or dihydrotestosterone. This receptor functions as a DNA-binding transcription factor and facilitates the regulation of gene expression. AR a role in mediating the proliferation and differentiation of endometrium.
Physical form
Membranes are suspended in 25 mM HEPES containing 1 mM EDTA, 10% glycerol, 10 mM sodium molybdate, pH 7.4. Actual concentration and specific binding capacity are provided with each lot.
存储类别
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
K Horie et al.
Human reproduction (Oxford, England), 7(10), 1461-1466 (1992-11-01)
The immunohistochemical localization of the androgen receptor in the human endometrium at various stages of the menstrual cycle and post-menopausal period, in decidua and placenta of early pregnancy, and in several pathological conditions of the endometrium has been investigated. At
A D Mooradian et al.
Endocrine reviews, 8(1), 1-28 (1987-02-01)
Though unnecessary for life itself, androgens are essential for the propagation of the species and for establishment and maintenance of the quality of life of males through their support of sexual behavior and function, muscle strength, and sense of well-being.
J D Marsh et al.
Circulation, 98(3), 256-261 (1998-08-11)
The role of androgens in producing cardiac hypertrophy by direct action on cardiac myocytes is uncertain. Accordingly, we tested the hypothesis that cardiac myocytes in adult men and women express an androgen receptor gene and that myocytes respond to androgens