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经验公式(希尔记法):
C9H12N2O5S
化学文摘社编号:
分子量:
260.27
NACRES:
NA.51
PubChem Substance ID:
UNSPSC Code:
41106305
EC Number:
237-735-3
MDL number:
产品名称
4-硫代尿苷, ≥98%
InChI
1S/C9H12N2O5S/c12-3-4-6(13)7(14)8(16-4)11-2-1-5(17)10-9(11)15/h1-2,4,6-8,12-14H,3H2,(H,10,15,17)/t4-,6-,7-,8-/m1/s1
InChI key
ZLOIGESWDJYCTF-XVFCMESISA-N
SMILES string
OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)N2C=CC(=S)NC2=O
biological source
synthetic (organic)
assay
≥98%
form
powder
solubility
water: 20 mg/mL, clear
storage temp.
−20°C
Quality Level
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Application
4-硫代尿苷可用于标记和分离新生RNA。
Biochem/physiol Actions
4-硫代尿苷可以用于评估新生RNA合成。它还可以增强位点特异性交联。4-硫代尿苷即使在缺乏特异性光活化的情况下也具有稳定性,因此也可以用作光亲和探针。也可以将其整合到RNA中。
General description
4-硫代尿苷是光反应性尿苷类似物。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Lukas Windhager et al.
Genome research, 22(10), 2031-2042 (2012-04-28)
RNA synthesis and decay rates determine the steady-state levels of cellular RNAs. Metabolic tagging of newly transcribed RNA by 4-thiouridine (4sU) can reveal the relative contributions of RNA synthesis and decay rates. The kinetics of RNA processing, however, had so
Tsutomu Suzuki et al.
Annual review of genetics, 45, 299-329 (2011-09-14)
Mitochondria are eukaryotic organelles that generate most of the energy in the cell by oxidative phosphorylation (OXPHOS). Each mitochondrion contains multiple copies of a closed circular double-stranded DNA genome (mtDNA). Human (mammalian) mtDNA encodes 13 essential subunits of the inner
Indira Memet et al.
Nucleic acids research, 45(9), 5359-5374 (2017-01-25)
In eukaryotes, the synthesis of ribosomal subunits, which involves the maturation of the ribosomal (r)RNAs and assembly of ribosomal proteins, requires the co-ordinated action of a plethora of ribosome biogenesis factors. Many of these cofactors remain to be characterized in
Jonathan Krell et al.
Genome research, 26(3), 331-341 (2015-12-25)
DNA damage activates TP53-regulated surveillance mechanisms that are crucial in suppressing tumorigenesis. TP53 orchestrates these responses directly by transcriptionally modulating genes, including microRNAs (miRNAs), and by regulating miRNA biogenesis through interacting with the DROSHA complex. However, whether the association between
Hidenori Tani et al.
RNA biology, 9(10), 1233-1238 (2012-10-05)
Changing the abundance of transcripts by regulated RNA degradation is a critical step in the control of various biological pathways. Recently, genome-wide inhibitor-free technologies for determining RNA stabilities in mammalian cells have been developed. In these methods, endogenous RNAs are
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