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安全信息

T4577

Sigma-Aldrich

Terodiline hydrochloride

≥98% (HPLC), solid

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别名:
Bicor, N-(1,1-Dimethylethyl)-alpha-methyl-gamma-phenylbenzenepropamine hydrochloride
经验公式（希尔记法）:
C20H27N·HCl
CAS号:
7082-21-5
分子量:
317.90
MDL编号:
MFCD00941402
PubChem化学物质编号:
329826797

检测方案

≥98% (HPLC)

形式

solid

颜色

white to off-white

溶解性

DMSO: >20 mg/mL

储存温度

−20°C

SMILES字符串

Cl.CC(CC(c1ccccc1)c2ccccc2)NC(C)(C)C

InChI

1S/C20H27N.ClH/c1-16(21-20(2,3)4)15-19(17-11-7-5-8-12-17)18-13-9-6-10-14-18;/h5-14,16,19,21H,15H2,1-4H3;1H

InChI key

RNGHAJVBYQPLAZ-UHFFFAOYSA-N

基因信息

human ... CACNA1A(773) , CACNA1B(774) , CACNA1C(775) , CACNA1D(776) , CACNA1E(777) , CACNA1F(778) , CACNA1G(8913) , CACNA1H(8912) , CACNA1I(8911) , CACNA1S(779) , CACNA2D1(781) , CACNA2D2(9254) , CACNA2D3(55799) , CACNA2D4(93589) , CACNB1(782) , CACNB2(783) , CACNB3(784) , CACNB4(785) , CACNG1(786) , CACNG2(10369) , CACNG3(10368) , CACNG4(27092) , CACNG5(27091) , CACNG6(59285) , CACNG7(59284) , CACNG8(59283) , CHRM1(1128) , CHRM2(1129) , CHRM3(1131) , CHRM4(1132) , CHRM5(1133)

生化/生理作用

Terodiline hydrochloride is a non-selective calcium channel antagonist with anticholinergic and vasodilatory activity.
Terodiline is known to increase corrected QT interval (QTc) and decrease resting heart rate in elderly patients. Furthermore, terodiline hydrochloride has been linked to cardiac arrhythmias1.

特点和优势

This compound is featured on the Calcium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

制备说明

Terodiline hydrochloride is soluble in DMSO at a concentration that is greater than 20 mg/ml.

象形图

Exclamation markEnvironment
GHS07,GHS09

警示用语：

Warning

危险声明

H302 - H319 - H400

危险分类

Acute Tox. 4 Oral - Aquatic Acute 1 - Eye Irrit. 2

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

法规信息

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S E Jones et al.
British journal of pharmacology, 125(6), 1138-1143 (1998-12-24)
Prolongation of the QT interval and malignant ventricular arrhythmia have been observed in patients administered terodiline for urinary incontinence. Since this adverse reaction might be caused by inhibition of delayed-rectifier K+ current (IK), we investigated whether clinically relevant (< or
R Webster et al.
Xenobiotica; the fate of foreign compounds in biological systems, 31(8-9), 633-650 (2001-09-25)
1. Torsades de pointes (TDP) is a potentially fatal ventricular tachycardia associated with increases in QT interval and monophasic action potential duration (MAPD). TDP is a side-effect that has led to withdrawal of several drugs from the market (e.g. terfenadine
Leah R Gerber et al.
PloS one, 5(8), e12230-e12230 (2010-09-03)
In polygynous mating systems, males often increase their fecundity via aggressive defense of mates and/or resources necessary for successful mating. Here we show that both male and female reproductive behavior during the breeding season (June-August) affect female fecundity, a vital
K Hartigan-Go et al.
Clinical pharmacology and therapeutics, 60(1), 89-98 (1996-07-01)
To study the cardiovascular and electrocardiographic (ECG) effects of the R(+)- and S(-)- enantiomers of terodiline. The racemic drug was previously used to treat detrusor instability but was withdrawn after it caused serious ventricular arrhythmias associated with prolongation of the
Ruth L Martin et al.
Journal of cardiovascular pharmacology, 48(5), 199-206 (2006-11-18)
Terodiline and tolterodine are drugs used to treat urinary incontinence. Terodiline was removed from the market in 1991 for proarrhythmia, whereas tolterodine has a generally benign clinical cardiac profile. To assess differences in the electrophysiologic actions of these drugs, we
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