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T4887

T-2毒素

Name: T-2毒素
Brand: SIGMA

from Fusarium sp., powder, ≥98% (HPLC)

别名:

12,13-环氧单端孢霉-9-烯-3,4,8,15-四醇-4,15-二醋酸酯-8-异戊酸酯, 4β,15-二乙酰氧基-3α-羟基-8α-(3-甲基丁酰氧基)-12,13-环氧单端孢霉-9-烯

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关于此项目

经验公式（希尔记法）:

C₂₄H₃₄O₉

化学文摘社编号:

21259-20-1

分子量:

466.52

UNSPSC Code:

85151701

NACRES:

NA.77

PubChem Substance ID:

24900234

EC Number:

244-297-7

Beilstein/REAXYS Number:

3575695

MDL number:

MFCD00871255

Assay:

≥98% (HPLC)

Form:

powder

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属性

biological source

Fusarium sp.

Quality Segment

200

assay

≥98% (HPLC)

form

powder

availability

not available in USA, Japan

color

white

solubility

chloroform: soluble 9.80-10.20 mg/mL, clear, colorless to faintly yellow, DMSO: freely soluble, petroleum ether: slightly soluble

storage temp.

−20°C

SMILES string

[H][C@]12O[C@]3([H])[C@H](O)[C@@H](OC(C)=O)[C@](C)([C@@]1(COC(C)=O)C[C@H](OC(=O)CC(C)C)C(C)=C2)[C@]34CO4

InChI

1S/C24H34O9/c1-12(2)7-18(27)32-16-9-23(10-29-14(4)25)17(8-13(16)3)33-21-19(28)20(31-15(5)26)22(23,6)24(21)11-30-24/h8,12,16-17,19-21,28H,7,9-11H2,1-6H3/t16-,17+,19+,20+,21+,22+,23+,24-/m0/s1

InChI key

BXFOFFBJRFZBQZ-QYWOHJEZSA-N

说明

Application

T-2 toxin can cause degenerative lesions in articular cartilage of rats⁸. Furthermore, immunotoxicity studies have reported that T-2 toxin can cause cell death in human lymphoid T cells and also induces cell membrane damage in B cells⁹.

Biochem/physiol Actions

The trichothecenes, such as T2 Toxin, are mycotoxins produced by fungi of the genus Fusarium. They are commonly present in foods and feed of cereal origin. T-2 toxin induces DNA damage and cell death on prolonged administration. These effects can be partially blocked by antioxidants, such as glutathione, coenzyme Q10, or α-tocopherol. Increases blood-brain barrier permeability and inhibits monoamine oxidase activity in brain.

Preparation Note

T-2 Toxin is soluble in chloroform at 9.80 - 10.20 mg/ml and yields a clear, colorless to faint yellow solution. Furthermore, the product is freely soluble in DMSO and slightly soluble in petroleum ether.

Analysis Note

Chromatographically purified

pictograms

GHS06

signalword

Danger

hcodes

H300 + H310 + H330,H315

pcodes

P260 - P262 - P264 - P280 - P302 + P352 + P310 - P304 + P340 + P310

Hazard Classifications

Acute Tox. 1 Dermal - Acute Tox. 1 Inhalation - Acute Tox. 1 Oral - Skin Irrit. 2

存储类别

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c