T4949
Taprostene sodium salt
≥98% (HPLC)
别名:
Rheocyclan, Sodium 3-[(Z)-[(3aR,4R,5R,6aS)-4-[(1E,3S)-3-cyclohexyl-3-hydroxy-1-propenyl]hexahydro-5-hydroxy-2H-cyclopenta[b]furan-2-ylidene]methyl]benzoate
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关于此项目
经验公式（希尔记法）:
C24H29NaO5
化学文摘社编号:
分子量:
420.47
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352202
MDL number:
Assay:
≥98% (HPLC)
assay
≥98% (HPLC)
color
off-white
mp
173-182.5 °C (lit.)
solubility
H2O: 26 mg/mL
storage temp.
2-8°C
SMILES string
[Na+].[H][C@]12C[C@@H](O)[C@H](\C=C\[C@@H](O)C3CCCCC3)[C@@]1([H])C\C(O2)=C\c4cccc(c4)C([O-])=O
InChI
1S/C24H30O5.Na/c25-21(16-6-2-1-3-7-16)10-9-19-20-13-18(29-23(20)14-22(19)26)12-15-5-4-8-17(11-15)24(27)28;/h4-5,8-12,16,19-23,25-26H,1-3,6-7,13-14H2,(H,27,28);/q;+1/p-1/b10-9+,18-12-;/t19-,20-,21-,22-,23+;/m1./s1
InChI key
KPQVOJYDUCZQEQ-REHYUDDHSA-M
Application
Taprostene has been used as an IP receptor agonist and was found to increase cAMP expression in human bronchial epithelial cells1.
Biochem/physiol Actions
Highly selective IP1 prostanoid receptor agonist.
Preparation Note
Taprostene is soluble in water at 26 mg/ml.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
法规信息
新产品
此项目有
Jakob Labus et al.
The Laryngoscope, 120(9), 1863-1871 (2010-08-31)
To estimate the effect of recovery of idiopathic sudden hearing loss under placebo (first aim) and under medical therapy (second aim). Systematic review and meta-analysis. A total of 1,674 studies published between January 1974 and April 2009 were found following
R L Jones et al.
Journal of cardiovascular pharmacology, 29(4), 525-535 (1997-04-01)
The specific prostacyclin (IP) receptor agonist cicaprost relaxed human pulmonary artery preparations precontracted with phenylephrine [50% inhibitory concentration (IC50) approximately 0.6 nM], U-46619 (IC50 approximately 0.9 nM), and K+ (approximately 40% maximal relaxation); endothelium removal had little effect on relaxant
R L Jones et al.
Prostaglandins, leukotrienes, and essential fatty acids, 72(4), 289-299 (2005-03-15)
The possibility that the prostacyclin analogues AFP-07 and cicaprost relax saphenous vein preparations of pig, guinea-pig and rabbit by simultaneously activating prostanoid EP4 and IP (prostacyclin) receptors was investigated using the high-affinity EP4 antagonist GW 627368. The IP receptor system
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| T4949-1MG | 04061826677179 |
| T4949-5MG | 04061832787343 |