Merck
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文件

安全信息

T5067

Sigma-Aldrich

Anti-TRPC3 antibody produced in rabbit

affinity isolated antibody, lyophilized powder

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别名:
Anti-Transient receptor potential cation channel, subfamily C, member 3
MDL编号:
MFCD02686005
NACRES:
NA.41

生物来源

rabbit

质量水平

200

偶联物

unconjugated

抗体形式

affinity isolated antibody

antibody product type

primary antibodies

克隆

polyclonal

形式

lyophilized powder

species reactivity

rat

浓度

≥0.6 mg/mL (after reconstitution)

technique(s)

western blot: suitable

UniProt登记号

Q9JMI9

储存温度

−20°C

target post-translational modification

unmodified

Gene Information

mouse ... Trpc3(22065)
rat ... Trpc3(60395)

一般描述

Transient receptor potential-canonical 3 (TRPC3) is a member of TRP superfamily. It is mainly expressed in brain. The TRPC3 gene is mapped to human chromosome 4.

免疫原

peptide corresponding to amino acid residues 822-835 of mouse TRPC3.

生化/生理作用

TRPC3 (transient receptor potential-canonical 3) participates in motility and capacitation of sperm. It is responsible for the proliferation of ovarian cancer cell in vitro and in vivo. TRPC3 plays a key role in a wide spectrum of Ca2+ signaling mechanisms. Elevated expression of TRPC3 has been observed in spontaneously hypertensive rats (SHR).

外形

Lyophilized from phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin, and 0.05% sodium azide

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

法规信息

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Activation of a TRPC3-Dependent Cation Current through the Neurotrophin BDNF
Li HS
Neuron, 24, 261-273 (1999)
Hideki Hino et al.
Anesthesiology, 133(5), 1077-1092 (2020-09-12)
Local anesthetics, particularly potent long acting ones such as bupivacaine, can cause cardiotoxicity by inhibiting sodium ion channels; however, the impact of left ventricular hypertrophy on the cardiotoxicity and the underlying mechanisms remain undetermined. Transient receptor potential canonical (TRPC) channels
Follicle-stimulating hormone enhances the proliferation of ovarian cancer cells by activating transient receptor potential channel C3
Tao X
Endocrine-Related Cancer, 20, 415-429 (2013)
TRPC3: A Multifunctional Signaling Molecule
Lichtenegger M and Groschner K
Handbook of Experimental Pharmacology, 67-84 (2014)
Genotype of an individual single nucleotide polymorphism regulates DNA methylation at the TRPC3 alternative promoter.
Martin-Trujillo A
Epigenetics, 6, 1236-1241 (2011)
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