T5134
(±)-α-Tocopherol nicotinate
别名:
Vitamin E nicotinate
方案
≥98%
表单
solid or liquid
颜色
white to yellow
储存温度
2-8°C
SMILES字符串
CC(C)CCC[C@@H](C)CCC[C@@H](C)CCC[C@]1(C)CCc2c(C)c(OC(=O)c3cccnc3)c(C)c(C)c2O1
InChI
1S/C35H53NO3/c1-24(2)13-9-14-25(3)15-10-16-26(4)17-11-20-35(8)21-19-31-29(7)32(27(5)28(6)33(31)39-35)38-34(37)30-18-12-22-36-23-30/h12,18,22-26H,9-11,13-17,19-21H2,1-8H3/t25-,26-,35-/m1/s1
InChI key
MSCCTZZBYHQMQJ-AZAGJHQNSA-N
一般描述
α-Tocopherol nicotinate is a fat soluble vitamin. It is an ester of tocopherol and niacin. Niacin is linked to the hydroxyl group of active vitamin E in this ester. α-Tocopherol is a form of vitamin E, which is available through dietary sources. RRR-α-tocopherol is a natural form of α-Tocopherol.
应用
(±)-α-Tocopherol nicotinate has been used in metabolic studies to assess its biological functions in rats.
生化/生理作用
α-Tocopherol is a radical-chain breaker owing to its anti-oxidant property.
Tocopherols (TCP) (vitamin E) are a series (α, β, γ and δ) of chiral organic molecules that vary in their degree of methylation of the phenol moiety of the chromanol ring. Tocopherols are lipid soluble anti-oxidants that protect cell membranes from oxidative damage. α-Tocopherol is the form of tocopherol preferentially absorbed by homo sapiens. α-Tocopherol nicotinate is used along the α-Tocopherol acetate, α-Tocopherol succinate and other esterified forms as a vitamin E supplement with similar but differential activities.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
H P Wu et al.
Journal of the Formosan Medical Association = Taiwan yi zhi, 91(3), 270-275 (1992-03-01)
Tocopherol has been shown to have antiplatelet effects in insulin-dependent diabetes mellitus. However, its antiplatelet effect in non-insulin-dependent diabetes mellitus (NIDDM) remains to be established. In this report, the antiplatelet effect of tocopherol was assessed in a randomized, double-blind and
H Yuasa et al.
Chemical & pharmaceutical bulletin, 42(11), 2327-2331 (1994-11-01)
Calcium silicate (Florite RE, FLR), a fine porous powder, was recently approved as a medicinal additive. In this study we sought to make a solid preparation by absorbing an oily medicine to FLR; tocopheryl nicotinate (TN) was used as the
Metabolomics Studies to Assess Biological Functions of Vitamin E Nicotinate
Marcocci L and Suzuki YJ
Antioxidants, 8(5), 127-127 (2019)
[Clinical effect of dentifrice containing dl-alpha-Tocopheryl nicotinate].
K Ikeda et al.
Nihon Shishubyo Gakkai kaishi, 24(4), 619-632 (1982-12-01)
P Schlieper et al.
Arzneimittel-Forschung, 37(8), 920-923 (1987-08-01)
The effect of alpha-tocopherol nicotinate (Renascin), alpha-tocopherol and dodecanoic acid (lauric acid) on the positive inotropic action of ouabain and digoxin and on cardiac glycoside induced arrhythmias has been tested in isolated guinea-pig left atria and in anaesthetized guinea-pigs. alpha-Tocopherol
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