T5200
曲帕拉醇
≥97% (HPLC), D24 reductase inhibitor, powder
别名:
1-(4-(2-Diethylaminoethoxy)phenyl)-1-p-tolyl-2-(4-chlorophenyl)ethanol
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关于此项目
经验公式（希尔记法）:
C27H32NO2Cl
化学文摘社编号:
分子量:
438.00
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
201-115-0
MDL number:
Assay:
≥97% (HPLC)
Form:
powder
产品名称
曲帕拉醇, ≥97% (HPLC), powder
Quality Segment
assay
≥97% (HPLC)
form
powder
color
white to off-white
mp
102.9-103.7 °C
solubility
DMSO: 20 mg/mL, H2O: insoluble, alcohol: soluble, olive oil: slightly soluble
storage temp.
2-8°C
SMILES string
CCN(CC)CCOc1ccc(cc1)C(O)(Cc2ccc(Cl)cc2)c3ccc(C)cc3
InChI
1S/C27H32ClNO2/c1-4-29(5-2)18-19-31-26-16-12-24(13-17-26)27(30,23-10-6-21(3)7-11-23)20-22-8-14-25(28)15-9-22/h6-17,30H,4-5,18-20H2,1-3H3
InChI key
SYHDSBBKRLVLFF-UHFFFAOYSA-N
Gene Information
human ... DHCR24(1718), EBP(10682)
Application
Triparanol has been used to inhibit cholesterol biosynthesis in lipid rafts1. Triparanol has also been used as a 3β-hydroxysterol-Δ24-reductase inhibitor to study its effect on delayed-rectifier potassium current (Iks) channels2.
Biochem/physiol Actions
Desmosterol Delta24 (D24) reductase inhibitor.
Triparanol is known to repress Hedgehog signaling in cancer cells and can also inhibit tumor growth3.
Preparation Note
Triparanol is soluble in DMSO at 20 mg/ml and is also soluble in alcohol. It is slightly soluble in olive oil and is insoluble in water.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Dam. 1
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves