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Merck
CN

T5300

Transforming Growth Factor-β2 来源于猪血小板

≥97% (SDS-PAGE and N-terminal analysis), recombinant, powder, suitable for cell culture

别名:

TGF-β2

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关于此项目

UNSPSC Code:
12352202
NACRES:
NA.77
MDL number:
Biological source:
Porcine (Platelets)
Assay:
≥97% (SDS-PAGE and N-terminal analysis)
Form:
powder
Mol wt:
protein 25 kDa
Impurities:
endotoxin, tested
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产品名称

Transforming Growth Factor-β2 来源于猪血小板, powder, suitable for cell culture

biological source

Porcine (Platelets)

assay

≥97% (SDS-PAGE and N-terminal analysis)

form

powder

potency

0.05-0.5 ng/mL ED50/EC50

mol wt

protein 25 kDa

packaging

pkg of 1 μg

storage condition

avoid repeated freeze/thaw cycles

technique(s)

cell culture | mammalian: suitable

impurities

endotoxin, tested

UniProt accession no.

storage temp.

−20°C

Quality Level

General description

TGF-β2 (transforming growth factor-β2) belongs to the TGF-β superfamily and the gene is mapped to pig (Sus scrofa) chromosome 10p16.

Biochem/physiol Actions

TGF-β2, like TGF-β1, is produced by many cell types and reported to be most concentrated in mammalian platelets.
TGF-β2 is responsible for maintaining immune homeostasis. TGF-β2 promotes cellular growth, differentiation and survival. TGF-β2 controls lymphocyte proliferation, apoptosis, hematopoiesis, and embryogenesis. TGF-β2 is a tumor suppress or in the early stages of carcinogenesis, but in the later stages acts as a tumor promoter by inducing epithelial-mesenchymal transition and stimulating angiogenesis. TGF-β2 prevents NK (natural killer) cells growth as well as B and T cell proliferation. TGF-β2 also greatly inhibits the growth of both normal and transformed epithelial. The growth of lymphoid, fibroblast and keratinocyte cells are also known to be hinder by TGF-β2. TGF-β2 controls intestinal homeostasis by functioning in synergy with the bacterial lipopolysaccharide and thereby maintain interleukin-8.
TGF-β2, like TGF-β1, is produced by many cell types and reported to be most concentrated in mammalian platelets.

TGF-β2 belongs to the TGF-β superfamily. TGF-β2 is important for immune homeostasis by balancing lymphocyte proliferation, apoptosis, hematopoiesis, and embryogenesis. TGF-β2 is crucial in cell growth, differentiation, and survival. TGF-β2 is a strong growth inhibitor for normal and transformed epithelial, lymphoid, fibroblast, and keratinocyte cells. TGF-β2 is a tumor suppress or in the early stages of carcinogenesis, but in the later stages acts as a tumor promoter by inducing epithelial-mesenchymal transition and stimulating angiogenesis. TGF-β2 inhibits NK cells growth as well as B and T cell proliferation.

Physical form

Lyophilized from a 0.2 μm filtered solution in 25% acetonitrile and 0.1% trifluoroacetic acid containing 0.05 mg bovine serum albumin.

Analysis Note

The biological activity is measured by its ability to inhibit the IL-4-dependent proliferation of mouse HT-2 cells.
The biological activity of porcine TGF-β2 was tested in culture by measuring its ability to inhibit thymidine incorporation in the IL-4 dependent mouse T-helper cell line HT-2. The EC50 is defined as the effective concentration of growth factor that elicits 50% inhibition of cell growth in a cell based bioassay.

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

法规信息

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Transforming growth factor-? induces epithelial to mesenchymal transition and suppresses the proliferation and transdifferentiation of cultured human pancreatic duct cells.
Hong OK, Shin JA, Lee HJ, Jeon SY
Journal of Cellular Biochemistry (2010)
Transforming growth factor-2 and endotoxin interact to regulate homeostasis via interleukin-8 levels in the immature intestine
Nguyen DN, et al.
American Journal of Physiology: Gastrointestinal and Liver Physiology, 307, G689- G699 (2014)
A Signaling Pathway Involving TGF-β2 and Snail in Hair Follicle Morphogenesis
Jamora C, et al.
PLoS Biology, 3.1 (2004)
Mapping of the porcine urate oxidase and transforming growth factor β 2 genes by fluorescence in situ hybridization.
Rettenberger G, et al.
Chromosome Research, 4(2), 147-150 (1996)
Tsang, M., et al.
Lymphokine Research, 9, 607-607 (1990)

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