T5443
Tyrphostin AG 825
≥92.5%
别名:
5-[(Benzothiazol-2-yl)thiomethyl]-4-hydroxy-3-methoxybenzylidenecyanoacetamide, Tyrphostin C15
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关于此项目
经验公式（希尔记法）:
C19H15N3O3S2
化学文摘社编号:
分子量:
397.47
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
质量水平
方案
≥92.5%
表单
powder
溶解性
DMSO: soluble
methanol: soluble
储存温度
−20°C
SMILES字符串
COc1cc(cc(CSc2nc3ccccc3s2)c1O)\C=C(/C#N)C(N)=O
InChI
1S/C19H15N3O3S2/c1-25-15-8-11(6-12(9-20)18(21)24)7-13(17(15)23)10-26-19-22-14-4-2-3-5-16(14)27-19/h2-8,23H,10H2,1H3,(H2,21,24)/b12-6+
InChI key
KXDONFLNGBQLTN-WUXMJOGZSA-N
相关类别
应用
Tyrphostin AG 825 has been used to study its effects on iodide uptake in EMT6 cells1.
生化/生理作用
EGF receptor tyrosine kinase inhibitor, inactive against IGF-1 Receptor.
Tyrphostin AG 825 has been used in combination with hypericin-mediated photodynamic therapy (HY-PDT) for evaluating its therapeutic effects in HER2 overexpressing human breast cancer cells. This study reported that AG 825 combination increased the induction of cell death, HER2 degradation and inhibited colony formation in cancer cells2.
特点和优势
This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
制备说明
Tyrphostin AG 825 is soluble in DMSO and methanol.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
Ján Koval et al.
Photochemistry and photobiology, 86(1), 200-205 (2009-11-17)
Current treatment of breast cancer is often affected by resistance to therapeutics, for which the human epidermal growth factor receptor 2 (HER2) may be responsible. Here, we report for the first time the use of hypericin-mediated photodynamic therapy (HY-PDT) in
Florian C Gaertner et al.
International journal of cancer, 125(12), 2783-2791 (2009-07-02)
The sodium iodide symporter (NIS) mediates iodide uptake into the thyroid. Because of this mechanism, differentiated thyroid cancer is susceptible for radioiodine therapy. Functional NIS expression in extrathyroidal tumors has been reported mainly in breast cancer. We screened colorectal tumors
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