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Merck
CN

T5639

替卡西林 二钠盐

别名:

(2S,5R,6R)-6-[[(2R)-Carboxy-3-thienylacetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid disodium salt

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关于此项目

经验公式（希尔记法）:
C15H14N2Na2O6S2
化学文摘社编号:
4697-14-7
分子量:
428.39
NACRES:
NA.85
PubChem Substance ID:
24900306
UNSPSC Code:
51282427
MDL number:
MFCD07787410

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InChI

1S/C15H16N2O6S2.2Na/c1-15(2)9(14(22)23)17-11(19)8(12(17)25-15)16-10(18)7(13(20)21)6-3-4-24-5-6;;/h3-5,7-9,12H,1-2H3,(H,16,18)(H,20,21)(H,22,23);;/q;2*+1/p-2/t7-,8-,9+,12-;;/m1../s1

SMILES string

[Na+].[Na+].CC1(C)S[C@@H]2[C@H](NC(=O)[C@H](C([O-])=O)c3ccsc3)C(=O)N2[C@H]1C([O-])=O

InChI key

ZBBCUBMBMZNEME-QBGWIPKPSA-L

biological source

semisynthetic

form

powder or crystals

color

white to light yellow

antibiotic activity spectrum

Gram-negative bacteria
Gram-positive bacteria

mode of action

cell wall synthesis | interferes

storage temp.

2-8°C

Quality Level

200

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相关类别

Application

Ticarcillin is a semisynthetic antibiotic with a broad spectrum of bactericidal activity against many gram-positive and gram-negative aerobic and anaerobic bacteria. It is commonly used in combination with clavulanate in order to improve it′s efficacy. It is used to study appropriate dosing in pediatric patients who have cystic fibrosis.

Biochem/physiol Actions

Ticarcillin is a β-Lactam antibiotic that prevents bacterial cell wall biosynthesis at the level of peptidogylcan cross-linking by inhibiting peptidoglycan transpeptidases. It is derived from penicillin and is similar to carbenicillin in action. Ticarcillin is susceptible to degradation by ß-lactamases.

General description

Chemical structure: ß-lactam

Other Notes

β-Lactam antibiotic
Keep container tightly closed in a dry and well-ventilated place. Moisture sensitive. Keep in a dry place.

Packaging

1G

Preparation Note

Keep container tightly closed in a dry and well-ventilated place. Moisture sensitive. Keep in a dry place.

pictograms

Health hazardExclamation mark
GHS08,GHS07

signalword

Danger

Hazard Classifications

Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

存储类别

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

法规信息

涉药品监管产品
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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000336878
0000336878
0000201448
0000240064
0000227605

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Müserref Tatman-Otkun et al.
BMC microbiology, 5, 24-24 (2005-05-11)
Stenotrophomonas maltophilia is inherently resistant to many antimicrobials. So far, antimicrobial susceptibility tests for S. maltophilia have not been fully standardized. The purpose of the study was to compare the susceptibility of S. maltophilia isolates against seven different antimicrobials using
R N Brogden et al.
Drugs, 20(5), 325-352 (1980-11-01)
Ticarcillin is a semisynthetic penicillin for parenteral administration. The antibacterial activity of ticarcillin is similar to that of carbenicillin except that it is two to four times more active in vitro against Pseudomonas aeruginosa, generally less active against Gram-positive cocci
Natalie A Peartree et al.
Psychopharmacology, 234(12), 1815-1828 (2017-04-01)
Smoking typically begins during adolescence or early adulthood in a social context, yet the role of social context in animal models is poorly understood. The present study examined the effect of social context on acquisition of nicotine self-administration. Sixty-day-old male
Rocio Ochoa-Fernandez et al.
Nature methods, 17(7), 717-725 (2020-07-01)
Optogenetics is the genetic approach for controlling cellular processes with light. It provides spatiotemporal, quantitative and reversible control over biological signaling and metabolic processes, overcoming limitations of chemically inducible systems. However, optogenetics lags in plant research because ambient light required
Jennifer M Loftis et al.
European journal of pharmacology, 880, 173175-173175 (2020-05-18)
There are no medications that target the neurotoxic effects or reduce the use of methamphetamine. Recombinant T-cell receptor ligand (RTL) 1000 [a partial major histocompatibility complex (pMHC) class II construct with a tethered myelin peptide], addresses the neuroimmune effects of
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Product Information Sheet - T5639

Product Information Sheet

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