T6069
三乙烯硫代磷酰胺
别名:
N,N′,N″-三乙撑硫代磷酰胺, 三(1-吖丙啶基)硫代磷酰, 三亚乙基硫代磷酰胺, 三胺硫磷, 噻替哌, 噻替派, 塞替派, 硫次膦基三氮丙啶
表单
solid
质量水平
储存条件
(Keep container tightly closed in a dry and well-ventilated place.)
颜色
white
抗生素抗菌谱
neoplastics
作用机制
DNA synthesis | interferes
储存温度
2-8°C
SMILES字符串
S=P(N1CC1)(N2CC2)N3CC3
InChI
1S/C6H12N3PS/c11-10(7-1-2-7,8-3-4-8)9-5-6-9/h1-6H2
InChI key
FOCVUCIESVLUNU-UHFFFAOYSA-N
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一般描述
化学结构：氮丙啶
应用
多官能烷基化剂
生化/生理作用
该不稳定的氮碳基团会与 DNA 烷基化，从而导致不可逆的 DNA 损伤。它们通过使 DNA 双螺旋链中的鸟嘌呤核苷交联来阻止肿瘤生长、直接攻击 DNA。DNA 链无法解开和分离，从而阻止了细胞分裂。
分析说明
溶解度 - 完全溶于水、氯仿和乙醇（96%）
其他说明
保存于密闭容器内，置于干燥通风处。
警示用语：
Danger
危险声明
危险分类
Acute Tox. 2 Oral - Carc. 1B
储存分类代码
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
WGK
WGK 3
个人防护装备
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Soo Hyeon Bae et al.
Chemico-biological interactions, 205(1), 11-19 (2013-06-20)
The present study was performed to evaluate the potency and specificity of sibutramine as an inhibitor of the activities of nine human CYP isoforms in liver microsomes. Using a cocktail assay, the effects of sibutramine on specific marker reactions of
Michael P Fay et al.
Statistics in medicine, 31(28), 3760-3772 (2012-07-13)
We consider weighted logrank tests for interval censored data when assessment times may depend on treatment, and for each individual, we only use the two assessment times that bracket the event of interest. It is known that treating finite right
A Fabi et al.
Annals of oncology : official journal of the European Society for Medical Oncology, 6(2), 187-189 (1995-02-01)
Vinorelbine as single-agent has achieved an overall response rate of > 20% as second-line treatment and 40%-50% as first-line treatment. The aim of this study was to evaluate the activity and toxicity of the combination of vinorelbine and thiotepa as
Maura Massimino et al.
Pediatric blood & cancer, 60(12), 2031-2035 (2013-07-16)
A protocol for the intensive treatment of non-cerebellar PNET (CNS-PNET) combining chemotherapy and radiotherapy was launched in 2000. Efforts were subsequently made to improve the prognosis and to de-escalate the treatment for selected patient groups. Twenty-eight consecutive patients were enrolled
Ulla M Saarinen-Pihkala et al.
Pediatric blood & cancer, 59(7), 1190-1197 (2012-04-12)
Outcome of high risk neuroblastoma (NBL) remains unsatisfactory in spite of intensive treatment efforts. Consolidation with high-dose (HD) chemotherapy and autologous stem cell transplantation (ASCT) has been intensified with tandem and triple cycles with promising results. Our purpose was to
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