T6069
三乙烯硫代磷酰胺
别名:
N,N′,N″-三乙撑硫代磷酰胺, 三(1-吖丙啶基)硫代磷酰, 三亚乙基硫代磷酰胺, 三胺硫磷, 噻替哌, 噻替派, 塞替派, 硫次膦基三氮丙啶
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关于此项目
经验公式（希尔记法）:
C6H12N3PS
化学文摘社编号:
分子量:
189.22
NACRES:
NA.85
PubChem Substance ID:
UNSPSC Code:
51102829
EC Number:
200-135-7
MDL number:
InChI key
FOCVUCIESVLUNU-UHFFFAOYSA-N
InChI
1S/C6H12N3PS/c11-10(7-1-2-7,8-3-4-8)9-5-6-9/h1-6H2
SMILES string
S=P(N1CC1)(N2CC2)N3CC3
form
solid
storage condition
(Keep container tightly closed in a dry and well-ventilated place.)
color
white
antibiotic activity spectrum
neoplastics
mode of action
DNA synthesis | interferes
storage temp.
2-8°C
Quality Level
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Analysis Note
溶解度 - 完全溶于水、氯仿和乙醇（96%）
Application
多官能烷基化剂
Biochem/physiol Actions
该不稳定的氮碳基团会与 DNA 烷基化，从而导致不可逆的 DNA 损伤。它们通过使 DNA 双螺旋链中的鸟嘌呤核苷交联来阻止肿瘤生长、直接攻击 DNA。DNA 链无法解开和分离，从而阻止了细胞分裂。
General description
化学结构：氮丙啶
Other Notes
保存于密闭容器内，置于干燥通风处。
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 2 Oral - Carc. 1B
存储类别
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
ppe
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
Soo Hyeon Bae et al.
Chemico-biological interactions, 205(1), 11-19 (2013-06-20)
The present study was performed to evaluate the potency and specificity of sibutramine as an inhibitor of the activities of nine human CYP isoforms in liver microsomes. Using a cocktail assay, the effects of sibutramine on specific marker reactions of
Michael P Fay et al.
Statistics in medicine, 31(28), 3760-3772 (2012-07-13)
We consider weighted logrank tests for interval censored data when assessment times may depend on treatment, and for each individual, we only use the two assessment times that bracket the event of interest. It is known that treating finite right
Sotirios G Papageorgiou et al.
Hematological oncology, 31(1), 10-17 (2012-05-23)
Central nervous system (CNS) involvement in patients with primary mediastinal large B-cell (PMLBCL) lymphoma is a rare event, occurring in approximately 6% of patients, on the basis of the review of the literature prior to induction of Rituximab. The aim
Maura Massimino et al.
Pediatric blood & cancer, 60(12), 2031-2035 (2013-07-16)
A protocol for the intensive treatment of non-cerebellar PNET (CNS-PNET) combining chemotherapy and radiotherapy was launched in 2000. Efforts were subsequently made to improve the prognosis and to de-escalate the treatment for selected patient groups. Twenty-eight consecutive patients were enrolled
J Sanz et al.
Bone marrow transplantation, 47(10), 1287-1293 (2012-02-14)
Attempts to optimize outcomes in cord blood transplantation (CBT) by using new conditioning regimens and standardization of cord blood unit selection are warranted. In all, 88 patients (18 children and 70 adults) with hematological malignancy from nine Spanish institutions underwent
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