Merck
CN

T6260

Sigma-Aldrich

牛磺鹅去氧胆酸钠

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别名:
2-([3α,7α-二羟基-24-氧代-5β-胆烷-24-基] 氨基)乙磺酸 钠盐, 3α,7α-二羟基-5β-胆烷-24-酸 N-(2-磺乙基)酰胺 钠盐, 牛磺鹅脱氧胆酸 钠盐
经验公式(希尔记法):
C26H44NNaO6S
CAS号:
分子量:
521.69
Beilstein:
3901205
MDL编号:
PubChem化学物质编号:
NACRES:
NA.25

描述

anionic

质量水平

检测方案

≥95.0% (TLC)

形式

powder

分子量

521.69 g/mol

CMC

4

HLB

20.1

官能团

sulfonic acid

运输

ambient

储存温度

room temp

SMILES string

[H][C@@]12[C@]([C@](CC[C@@H](O)C3)(C)[C@]3([H])C[C@H]2O)([H])CC[C@@]4(C)[C@@]1([H])CC[C@]4([H])[C@]([H])(C)CCC(NCCS(=O)([O-])=O)=O.[Na+]

InChI

1S/C26H45NO6S.Na/c1-16(4-7-23(30)27-12-13-34(31,32)33)19-5-6-20-24-21(9-11-26(19,20)3)25(2)10-8-18(28)14-17(25)15-22(24)29;/h16-22,24,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33);/q;+1/p-1/t16-,17+,18-,19-,20+,21+,22-,24?,25+,26-;/m1./s1

InChI key

IYPNVUSIMGAJFC-ULWOGUKGSA-M

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一般描述

一种离子洗涤剂,用于溶解脂肪和蛋白质。
牛磺鹅去氧胆酸钠是一种胆汁酸,可用作阴离子洗涤剂。

应用

牛磺鹅去氧胆酸钠已用于一项研究,以评估胰岛 β-细胞有助于 BA 依赖的葡萄糖调节。 也被用于研究胆汁酸盐 在体内对牛磺胆酸钠共转运多肽 (Ntcp) 的短期反馈调节

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)


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Kalaimathi Govindarajan et al.
PloS one, 11(12), e0167319-e0167319 (2016-12-03)
Disruptions to circadian rhythm in mice and humans have been associated with an increased risk of obesity and metabolic syndrome. The gut microbiota is known to be essential for the maintenance of circadian rhythm in the host suggesting a role
T M Zaved Waise et al.
Molecular metabolism, 44, 101132-101132 (2020-12-03)
The mechanism of nutrient sensing in the upper small intestine (USI) and ileum that regulates glucose homeostasis remains elusive. Short-term high-fat (HF) feeding increases taurochenodeoxycholic acid (TCDCA; an agonist of farnesoid X receptor (FXR)) in the USI and ileum of
B I Cohen et al.
Journal of lipid research, 18(2), 223-231 (1977-03-01)
Sterol metabolism studies using a combination of isotopic and chromatographic procedures were carried out in rats fed either a low-cholesterol stock diet or a stock diet containing 0.1% cholesterol. The primary bile acids, sodium taurochenodeoxycholate and sodium taurocholate, were added
Noritaka Kawasaki et al.
Scientific reports, 2, 799-799 (2012-11-15)
Adipose tissue plays a central role in maintaining metabolic homeostasis under normal conditions. Metabolic diseases such as obesity and type 2 diabetes are often accompanied by chronic inflammation and adipose tissue dysfunction. In this study, we observed that endoplasmic reticulum
M B Jiménez-Castro et al.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 12(12), 3257-3271 (2012-09-22)
Numerous steatotic livers are discarded for transplantation because of their poor tolerance to ischemia-reperfusion (I/R). We examined whether tauroursodeoxycholic acid (TUDCA), a known inhibitor of endoplasmic reticulum (ER) stress, protects steatotic and nonsteatotic liver grafts preserved during 6 h in

商品

Probiotics exhibit an inhibitory effect on pathogens, help prevent chronic intestinal inflammatory diseases or atopic syndromes, and support the immune system.

实验方案

This method is particularly useful in research into the role of individual bile acids as signaling molecules; suitable for clinical laboratories to investigate potential mechanisms linked to gut hormone profiles and glycemic control.

相关内容

Bile Acids (BA) are synthesized in the liver and play important roles in cholesterol homeostasis, absorption of vitamins and lipids, and various key metabolic processes.

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