主要文件

查看所有文档

T6330

THI

Name: THI
Brand: SIGMA

sphingosine-1-phosphate lyase inhibitor, powder

别名:

2-ATHBI, 2-乙酰基-4-四羟基丁基咪唑；1-[5- [(1R,2S,3R)-1,2,3,4-四羟基丁基]-1H-咪唑-2-基]-乙酮

登录查看组织和合同定价。

选择尺寸

变更视图

关于此项目

经验公式（希尔记法）:

C₉H₁₄N₂O₅

化学文摘社编号:

94944-70-4

分子量:

230.22

UNSPSC Code:

12352211

PubChem Substance ID:

329826636

NACRES:

NA.77

MDL number:

MFCD08752516

Form:

powder

Quality level:

100

技术服务

需要帮助？我们经验丰富的科学家团队随时乐意为您服务。

让我们为您提供帮助

产品名称

THI,

form

powder

Quality Level

100

color

white to light brown

solubility

DMSO: 2 mg/mL, clear (warmed)

storage temp.

2-8°C

SMILES string

CC(=O)c1nc(c[nH]1)[C@@H](O)[C@H](O)[C@H](O)CO

InChI

1S/C9H14N2O5/c1-4(13)9-10-2-5(11-9)7(15)8(16)6(14)3-12/h2,6-8,12,14-16H,3H2,1H3,(H,10,11)/t6-,7-,8-/m1/s1

InChI key

CQSIXFHVGKMLGQ-BWZBUEFSSA-N

正在寻找类似产品? 访问产品对比指南

Biochem/physiol Actions

THI 是鞘氨醇-1-磷酸裂解酶的抑制剂，起到免疫抑制剂的作用。

THI 是鞘氨醇-1-磷酸裂解酶的抑制剂，起到免疫抑制剂的作用。鞘氨醇-1-磷酸 (S1P) 裂解酶催化 S1P 不可逆地分解为十六醛和磷酸乙醇胺。减少 S1P 裂解酶活性导致免疫抑制的治疗水平，而没有合成的 S1P 受体激动剂导致的非淋巴病变。

已知 2-乙酰基-4-四羟基丁基咪唑 (THI) 可诱导大鼠外周血淋巴细胞减少。大鼠研究也有报道 THI 可影响淋巴细胞迁移和降解。

Preparation Note

THI 可溶于 DMSO，浓度大于 5 mg/mL。

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

0000523096

0000255823

0000130647

没有发现合适的版本？

如果您需要特殊版本，可通过批号或批次号查找具体证书。

搜索COA

已有该产品？

在文件库中查找您最近购买产品的文档。

访问文档库

The immunosuppressive compound 2-acetyl-4-tetrahydroxybutyl imidazole inhibits the allogeneic mixed lymphocyte reaction by sequestration of a recirculating subpopulation of T cells.

M G Bradbury et al.

Immunology, 87(1), 80-85 (1996-01-01)

2-acetyl-4(5)-(1,2,3,4-tetrahydroxybutyl)imidazole (THI) is an immunosuppressive component of caramel food colouring that causes lymphopenia in mice and rats by an unknown mechanism. In this study we investigated some of the affects of THI on the murine immune system. Initially we showed

The immunomodulatory compound 2-acetyl-4-tetrahydroxybutyl imidazole causes sequestration of lymphocytes in non-lymphoid tissues.

M G Bradbury et al.

Immunology and cell biology, 75(5), 497-502 (1998-01-16)

2-Acetyl-4(5)-(1,2,3,4-tetrahydroxybutyl) imidazole (THI) is an immunomodulatory compound which causes a reversible lymphopenia in mice by an unknown mechanism. In this study, we investigated the whereabouts of cells lost from the blood and the spleen during THI treatment Homing studies following

Pyridoxine supplementation protects mice from suppression of contact hypersensitivity induced by 2-acetyl-4-tetrahydroxybutylimidazole (THI), ultraviolet B radiation (280-320 nm), or cis-urocanic acid.

V E Reeve et al.

The American journal of clinical nutrition, 61(3), 571-576 (1995-03-01)

Evidence exists implicating the epidermal ultraviolet B (UVB) photoproduct cis-urocanic acid as an immunogenic mediator of the systemic suppression of T cell-mediated immunity by UVB exposure. Cis-urocanic acid appears to act via histamine receptor pathways, and histamine receptor antagonists and

Prevention of spontaneous and cyclophosphamide-induced diabetes in non-obese diabetic (NOD) mice with oral 2-acetyl-4-tetrahydroxybutylimidazole (THI), a component of caramel colouring III.

T E Mandel et al.

Clinical and experimental immunology, 88(3), 414-419 (1992-06-01)

The effect of oral administration of THI, a compound present in ammonia caramel food colouring, was studied in spontaneous and induced murine diabetes mellitus. Continuous administration of THI at 400 ppm in drinking water reduced the prevalence of spontaneous diabetes

Pharmacological Elevation of Circulating Bioactive Phosphosphingolipids Enhances Myocardial Recovery After Acute Infarction.

Yuri M Klyachkin et al.

Stem cells translational medicine, 4(11), 1333-1343 (2015-09-16)

Acute myocardial infarction (AMI) triggers mobilization of bone marrow (BM)-derived stem/progenitor cells (BMSPCs) through poorly understood processes. Recently, we postulated a major role for bioactive lipids such as sphingosine-1 phosphate (S1P) in mobilization of BMSPCs into the peripheral blood (PB).

查看所有相关文献

商品

Discover Bioactive Small Molecules for Lipid Signaling Research

全球贸易项目编号

货号	GTIN
T6330-25MG	04061833226872
T6330-5MG	04061833226889
T6330-1MG	04061826694633

我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系客户支持