T6330
THI
sphingosine-1-phosphate lyase inhibitor, powder
别名:
2-ATHBI, 2-乙酰基-4-四羟基丁基咪唑；1-[5- [(1R,2S,3R)-1,2,3,4-四羟基丁基]-1H-咪唑-2-基]-乙酮
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关于此项目
经验公式（希尔记法）:
C9H14N2O5
化学文摘社编号:
分子量:
230.22
UNSPSC Code:
12352211
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Form:
powder
Quality level:
产品名称
THI,
SMILES string
CC(=O)c1nc(c[nH]1)[C@@H](O)[C@H](O)[C@H](O)CO
InChI key
CQSIXFHVGKMLGQ-BWZBUEFSSA-N
InChI
1S/C9H14N2O5/c1-4(13)9-10-2-5(11-9)7(15)8(16)6(14)3-12/h2,6-8,12,14-16H,3H2,1H3,(H,10,11)/t6-,7-,8-/m1/s1
form
powder
color
white to light brown
solubility
DMSO: 2 mg/mL, clear (warmed)
storage temp.
2-8°C
Quality Level
相关类别
Biochem/physiol Actions
THI 是鞘氨醇-1-磷酸裂解酶的抑制剂，起到免疫抑制剂的作用。
THI 是鞘氨醇-1-磷酸裂解酶的抑制剂，起到免疫抑制剂的作用。鞘氨醇-1-磷酸 (S1P) 裂解酶催化 S1P 不可逆地分解为十六醛和磷酸乙醇胺。减少 S1P 裂解酶活性导致免疫抑制的治疗水平，而没有合成的 S1P 受体激动剂导致的非淋巴病变。
已知 2-乙酰基-4-四羟基丁基咪唑 (THI) 可诱导大鼠外周血淋巴细胞减少。大鼠研究也有报道 THI 可影响淋巴细胞迁移和降解 。
Preparation Note
THI 可溶于 DMSO，浓度大于 5 mg/mL。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
M G Bradbury et al.
Immunology, 87(1), 80-85 (1996-01-01)
2-acetyl-4(5)-(1,2,3,4-tetrahydroxybutyl)imidazole (THI) is an immunosuppressive component of caramel food colouring that causes lymphopenia in mice and rats by an unknown mechanism. In this study we investigated some of the affects of THI on the murine immune system. Initially we showed
M G Bradbury et al.
Immunology and cell biology, 75(5), 497-502 (1998-01-16)
2-Acetyl-4(5)-(1,2,3,4-tetrahydroxybutyl) imidazole (THI) is an immunomodulatory compound which causes a reversible lymphopenia in mice by an unknown mechanism. In this study, we investigated the whereabouts of cells lost from the blood and the spleen during THI treatment Homing studies following
V E Reeve et al.
The American journal of clinical nutrition, 61(3), 571-576 (1995-03-01)
Evidence exists implicating the epidermal ultraviolet B (UVB) photoproduct cis-urocanic acid as an immunogenic mediator of the systemic suppression of T cell-mediated immunity by UVB exposure. Cis-urocanic acid appears to act via histamine receptor pathways, and histamine receptor antagonists and
G F Houben et al.
Toxicology and applied pharmacology, 113(1), 43-54 (1992-03-01)
Administration of ammonia caramel color (AC) to rats may decrease blood lymphocyte counts, specifically in rats fed a diet low in vitamin B6. This effect is associated with 2-acetyl-4(5)-(1,2,3,4-tetrahydroxybutyl)imidazole (THI). To characterize and compare the effects of AC and THI
G F Houben et al.
Fundamental and applied toxicology : official journal of the Society of Toxicology, 20(1), 30-37 (1993-01-01)
Administration of the color additive caramel color III (AC) may cause a reduction in total white blood cell counts in rats due to reduced lymphocyte counts. Beside lymphopenia, several other effects in rat have been described. The effects are caused
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