T6330
THI
sphingosine-1-phosphate lyase inhibitor, powder
别名:
2-ATHBI, 2-乙酰基-4-四羟基丁基咪唑；1-[5- [(1R,2S,3R)-1,2,3,4-四羟基丁基]-1H-咪唑-2-基]-乙酮
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关于此项目
经验公式（希尔记法）:
C9H14N2O5
化学文摘社编号:
分子量:
230.22
MDL编号:
UNSPSC代码:
12352211
PubChem化学物质编号:
NACRES:
NA.77
生化/生理作用
THI 是鞘氨醇-1-磷酸裂解酶的抑制剂，起到免疫抑制剂的作用。
THI 是鞘氨醇-1-磷酸裂解酶的抑制剂，起到免疫抑制剂的作用。鞘氨醇-1-磷酸 (S1P) 裂解酶催化 S1P 不可逆地分解为十六醛和磷酸乙醇胺。减少 S1P 裂解酶活性导致免疫抑制的治疗水平，而没有合成的 S1P 受体激动剂导致的非淋巴病变。
已知 2-乙酰基-4-四羟基丁基咪唑 (THI) 可诱导大鼠外周血淋巴细胞减少。大鼠研究也有报道 THI 可影响淋巴细胞迁移和降解 。
制备说明
THI 可溶于 DMSO，浓度大于 5 mg/mL。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Jaap P P Saers et al.
Journal of human evolution, 135, 102654-102654 (2019-08-30)
The human foot is highly derived relative to that of other hominoids and therefore a topic of intense research in paleoanthropology. While trabecular bone is thought to be highly plastic in response to habitual behavior, knowledge of how trabecular structure
Dominic Englert et al.
Scientific reports, 7(1), 16182-16182 (2017-11-25)
Systemic neonicotinoids are commonly used in forest pest management programs. Senescent leaves containing neonicotinoids may, however, fall from treated trees into nearby streams. There, leaf-shredding invertebrates are particularly exposed due to their diet (feeding on neonicotinoid-contaminated leaves) or collaterally via
Paige V McDonald et al.
Journal of dairy science, 103(4), 3447-3458 (2020-02-06)
Heat-stressed dairy cows on pasture will compete for resources that aid cooling, but it is not known how heat stress affects the competition for water by indoor-housed cows. The aim of this observational study was to evaluate how heat stress
K V Nordlund et al.
Journal of dairy science, 102(7), 6495-6507 (2019-04-30)
Heat load is a challenge for high-producing dairy cows, with adverse consequences on production, reproduction, and welfare. The objectives of this observational study in 2 commercial dairy herds were to determine the effects of environmental heat stress on standing and
Christopher J Thorpe et al.
PloS one, 13(3), e0194810-e0194810 (2018-03-27)
The importance of patch quality for amphibians is frequently overlooked in distribution models. Here we demonstrate that it is highly important for the persistence of endemic and endangered amphibians found in the threatened and fragile ecosystems that are the rocky
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