T6394
噻吗洛尔 马来酸盐
≥98% (TLC), β-adrenoceptor antagonist, powder
别名:
(S)-3-[3-(叔丁基氨基)-2-羟基丙氧基]-4-吗啉基-1,2,5-噻二唑马来酸盐 马来酸盐, (S)-马来酸噻吗洛尔
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关于此项目
经验公式（希尔记法）:
C13H24N4O3S · C4H4O4
化学文摘社编号:
分子量:
432.49
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
248-111-5
MDL number:
Assay:
≥98% (TLC)
Form:
powder
产品名称
噻吗洛尔 马来酸盐, ≥98% (TLC), powder
Quality Segment
assay
≥98% (TLC)
form
powder
optical activity
[α]25/D -5.4°, c = 4.9 in 1 M HCl(lit.)
color
white to off-white
mp
202-203 °C (lit.)
solubility
H2O: soluble, ethanol: soluble
ε (extinction coefficient)
8,700 at 294 nm at 1 M
originator
Merck & Co., Inc., Kenilworth, NJ, U.S.
SMILES string
[H]\C(=C(/[H])C(O)=O)C(O)=O.CC(C)(C)NC[C@H](O)COc1nsnc1N2CCOCC2
InChI
1S/C13H24N4O3S.C4H4O4/c1-13(2,3)14-8-10(18)9-20-12-11(15-21-16-12)17-4-6-19-7-5-17;5-3(6)1-2-4(7)8/h10,14,18H,4-9H2,1-3H3;1-2H,(H,5,6)(H,7,8)/b;2-1-/t10-;/m0./s1
InChI key
WLRMANUAADYWEA-NWASOUNVSA-N
Gene Information
human ... ADRB1(153), ADRB2(154), ADRB3(155)
Application
Timolol maleate has been used as an adrenergic β-blocker for evaluating cardiovascular functions in mice5. It has also been used for evaluating the uptake of 86Rb+ in rat cardiomyocytes6.
Biochem/physiol Actions
Timolol maleate is a class II anti-arrhythmic agent that functions as a non-selective β-adrenoceptor antagonist, a vasodilator and an anti-glaucoma agent. Studies have reported that timolol maleate can be used for the treatment of infantile hemangioma (IH)7.
Features and Benefits
This compound was developed by Merck & Co., Inc., Kenilworth, NJ, U.S.. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
Preparation Note
Timolol maleate is soluble in ethanol and water.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Repr. 2
存储类别
11 - Combustible Solids
wgk
WGK 3
ppe
Eyeshields, Gloves, type P3 (EN 143) respirator cartridges