质量水平
方案
≥98% (TLC)
表单
powder
旋光性
[α]25/D -5.4°, c = 4.9 in 1 M HCl(lit.)
颜色
white to off-white
mp
202-203 °C (lit.)
溶解性
H2O: soluble
ethanol: soluble
ε (消光系数)
8,700 at 294 nm at 1 M
创始人
Merck & Co., Inc., Kenilworth, NJ, U.S.
SMILES字符串
[H]\C(=C(/[H])C(O)=O)C(O)=O.CC(C)(C)NC[C@H](O)COc1nsnc1N2CCOCC2
InChI
1S/C13H24N4O3S.C4H4O4/c1-13(2,3)14-8-10(18)9-20-12-11(15-21-16-12)17-4-6-19-7-5-17;5-3(6)1-2-4(7)8/h10,14,18H,4-9H2,1-3H3;1-2H,(H,5,6)(H,7,8)/b;2-1-/t10-;/m0./s1
InChI key
WLRMANUAADYWEA-NWASOUNVSA-N
基因信息
human ... ADRB1(153), ADRB2(154), ADRB3(155)
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应用
Timolol maleate has been used as an adrenergic β-blocker for evaluating cardiovascular functions in mice5. It has also been used for evaluating the uptake of 86Rb+ in rat cardiomyocytes6.
生化/生理作用
Timolol maleate is a class II anti-arrhythmic agent that functions as a non-selective β-adrenoceptor antagonist, a vasodilator and an anti-glaucoma agent. Studies have reported that timolol maleate can be used for the treatment of infantile hemangioma (IH)7.
特点和优势
This compound was developed by Merck & Co., Inc., Kenilworth, NJ, U.S.. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
制备说明
Timolol maleate is soluble in ethanol and water.
警示用语：
Warning
危险声明
危险分类
Acute Tox. 4 Oral - Repr. 2
储存分类代码
11 - Combustible Solids
WGK
WGK 3
个人防护装备
Eyeshields, Gloves, type P3 (EN 143) respirator cartridges
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