T6448
Anti-TREK-1 antibody produced in rabbit
affinity isolated antibody, buffered aqueous solution
别名:
Anti-Kcnk2, Anti-Potassium Channel K2P2.1, Anti-TWIK-related K+ channel 1
产品名称
Anti-TREK-1 antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
rat
technique(s)
western blot (chemiluminescent): 1:200 using rat brain membranes
UniProt accession no.
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... KCNK2(3776)
rat ... Kcnk2(170899)
Biochem/physiol Actions
The antibody reacts with rat TREK-1 (confirmed). It is expected that the antibody will also react with human and mouse TREK-1 due to sequence homology (17/18).
Potassium two pore domain channel subfamily K member 2 (KCNK2) possesses a potassium channel activity. It has a role in stabilizing the resting membrane potential of cells. The protein is also involved in the development of rat heart. TREK-1 could act as a drug target to treat acute heart ischemia.
Application
Anti-TREK-1 antibody produced in rabbit has been used in western blotting.
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Western Blotting (1 paper)
Western Blotting (1 paper)
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
General description
Potassium two pore domain channel subfamily K member 2 (KCNK2), also known as TWIK-related K+ channel-1 (TREK1), is expressed in the spinal cord, bladder and dorsal root ganglion. It is part of the TREK family.
Immunogen
synthetic peptide (DPKSA AQNSK PRLSF STKC) corresponding to the intracellular, amino terminus of human TREK-1 (amino acid residues 8-28).
Physical form
Lyophilized from phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 0.05% sodium azide.
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存储类别
12 - Non Combustible Liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
常规特殊物品
此项目有
Naaz Andharia et al.
Channels (Austin, Tex.), 11(3), 224-235 (2017-01-14)
The TREK-1 channel, the TWIK-1-related potassium (K
Effects of fluoxetine on protein expression of potassium ion channels in the brain of chronic mild stress rats
Chunlin C, et al.
Acta Pharmaceutica Sinica. B, 5(1), 55-61 (2015)
Increased Expression of TREK-1 K+ Channel in the Dorsal Root Ganglion of Rats with Detrusor Overactivity After Partial Bladder Outlet Obstruction
Junlong Z,et al.
Medical Science Monitor : International Medical Journal of Experimental and Clinical Research, 24, 1064-1064 (2018)
Analysis of gene expression profiles in the programmed cell death rat retinal ganglion cells (RGC-5).
Abdelnaby K, et al.
Cancer Therapy, 6(2) (2008)
Chunlin Chen et al.
Acta pharmaceutica Sinica. B, 5(1), 55-61 (2015-11-19)
The purpose of this study is to investigate the expression of major potassium channel subtypes in the brain of chronical mild stress (CMS) rats and reveal the effects of fluoxetine on the expression of these channels. Rats were exposed to
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