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Merck
CN

T6514

Oleandomycin triacetate

别名:

Troleandomycin

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关于此项目

经验公式(希尔记法):
C41H67NO15
化学文摘社编号:
分子量:
813.97
UNSPSC Code:
51101500
EC Number:
220-392-9
Beilstein/REAXYS Number:
1418238
MDL number:
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SMILES string

CO[C@H]1C[C@@H](O[C@@H](C)[C@@H]1OC(C)=O)O[C@H]2[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@@H]([C@H]3OC(C)=O)N(C)C)[C@@H](C)C[C@@]4(CO4)C(=O)[C@H](C)[C@@H](OC(C)=O)[C@@H](C)[C@@H](C)OC(=O)[C@@H]2C

mode of action

enzyme | inhibits, protein synthesis | interferes

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General description

Chemical structure: macrolide

wgk

WGK 2

存储类别

13 - Non Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

法规信息

涉药品监管产品
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分析证书(COA)

Lot/Batch Number

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Daniel R Albaugh et al.
Drug metabolism and disposition: the biological fate of chemicals, 40(7), 1336-1344 (2012-04-12)
The current studies assessed the utility of freshly plated hepatocytes, cryopreserved plated hepatocytes, and cryopreserved plated HepaRG cells for the estimation of inactivation parameters k(inact) and K(I) for CYP3A. This was achieved using a subset of CYP3A time-dependent inhibitors (fluoxetine
Soo H Bae et al.
The Journal of pharmacy and pharmacology, 61(12), 1637-1642 (2009-12-05)
It has been reported that hepatic cytochrome P450 (CYP)2C9 and CYP3A4 are responsible for the metabolism of sildenafil and formation of its metabolite, N-desmethylsildenafil, in humans. However, in-vivo studies in rats have not been reported. Sildenafil (20 mg/kg) was administered
Shobana Ganesan et al.
Toxicology and applied pharmacology, 241(1), 14-22 (2009-07-21)
Primaquine, an 8-aminoquinoline, is the drug of choice for radical cure of relapsing malaria. Use of primaquine is limited due to its hemotoxicity, particularly in populations with glucose-6-phosphate dehydrogenase deficiency [G6PD(-)]. Biotransformation appears to be central to the anti-infective and
Güliz Gürel et al.
Antimicrobial agents and chemotherapy, 53(12), 5010-5014 (2009-09-10)
Structures have been obtained for the complexes that triacetyloleandomycin and mycalamide A form with the large ribosomal subunit of Haloarcula marismortui. Triacetyloleandomycin binds in the nascent peptide tunnel and inhibits the activity of ribosomes by blocking the growth of the
Yu Liu et al.
Comparative medicine, 58(6), 580-587 (2009-01-20)
The objective of this study was to demonstrate that Bama miniature pigs are a suitable experimental animal model for the evaluation of drugs for man. To this end, in vitro lovastatin metabolism at the minipig liver microsomal level and in

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