T6515
胆囊收缩素片段30-33酰胺
≥95% (HPLC)
别名:
CCK-4, Trp-Met-Asp-苯乙酰胺, 四胃泌素 盐酸盐, 胃泌素四肽
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关于此项目
经验公式（希尔记法）:
C29H36N6O6S
化学文摘社编号:
分子量:
596.70
NACRES:
NA.32
PubChem Substance ID:
UNSPSC Code:
12352202
MDL number:
Form:
powder
Assay:
≥95% (HPLC)
Mol wt:
59670 g/mol
Quality Level
assay
≥95% (HPLC)
form
powder
mol wt
59670 g/mol
technique(s)
toxicology assay: suitable
solubility
DMF: 20 mg/mL, clear, colorless to yellow
suitability
suitable for molecular biology
storage temp.
−20°C
SMILES string
CSCC[C@H](NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc3ccccc3)C(N)=O
InChI
1S/C29H36N6O6S/c1-42-12-11-22(33-27(39)20(30)14-18-16-32-21-10-6-5-9-19(18)21)28(40)35-24(15-25(36)37)29(41)34-23(26(31)38)13-17-7-3-2-4-8-17/h2-10,16,20,22-24,32H,11-15,30H2,1H3,(H2,31,38)(H,33,39)(H,34,41)(H,35,40)(H,36,37)/t20-,22-,23-,24-/m0/s1
InChI key
RGYLYUZOGHTBRF-BIHRQFPBSA-N
Gene Information
human ... CCK(885)
rat ... Cckbr(25706)
General description
研究领域：神经科学
大脑中具有神经肽胆囊收缩素（CCK）的多个生物活性片段，它们在大脑中与CCK-A和 CCK-B受体相互作用。 在这些片段中，CCK-4在皮层和脑边缘系统中含量特别丰富。作为胆囊收缩素的生物活性形式，CCK-4是一种肽激素，通过结合肠道和脑中的CCK受体来调节食物摄入。
大脑中具有神经肽胆囊收缩素（CCK）的多个生物活性片段，它们在大脑中与CCK-A和 CCK-B受体相互作用。 在这些片段中，CCK-4在皮层和脑边缘系统中含量特别丰富。作为胆囊收缩素的生物活性形式，CCK-4是一种肽激素，通过结合肠道和脑中的CCK受体来调节食物摄入。
Application
胆囊收缩素片段 30-33 酰胺可用于灭活 CCK8 抗血清。 该产品也可用作吸收控制中的抗原，用于测试抗血清的特异性。胆囊收缩素片段 30-33 酰胺用于诱导小鼠中的抗焦虑和抗抑郁作用，并用于研究神经肽Y的作用。
Biochem/physiol Actions
胆囊收缩素片段 30-33 酰胺也称为 CCK-4 或 Trp-Met-Asp-Phe 酰胺是衍生自肽激素胆囊收缩素的肽片段。CCK-4 是引起人惊恐发作的惊恐试剂。化合物的这种性质可用于测试新抗焦虑药的科学研究。CCK-4 通过CCK-B受体选择性地起作用，其在情绪性行为调节中的作用得到广泛认可。 CCK 敲低小鼠研究表明其具有抗焦虑和抗抑郁作用。
Packaging
无底玻璃瓶。内含物装在插入的融合锥内。
Preparation Note
胆囊收缩素片段 30-33 酰胺溶于二甲基甲酰胺中，浓度为 20 mg/ml，得到澄清、无色至黄色的溶液。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
监管及禁止进口产品
此项目有
H Fink et al.
Experimental brain research, 123(1-2), 77-83 (1998-12-03)
Cholecystokinin (CCK) is one of the first discovered gastrointestinal hormones and one of the most abundant neuropeptides in the brain. Two types of CCK receptors have been identified: (1) CCK-A receptors are mainly located in the periphery, but are also
Kim Hinkelmann et al.
Journal of psychiatric research, 44(16), 1148-1153 (2010-05-11)
Cholecystokinin-tetrapeptide (CCK-4) is an established model to generate subjective panic anxiety. CCK-4 injection also results in consistent and dose-dependent rise of stress hormones. Effects other than upon subjective panic and stress hormone activity have barely been examined. The purpose of
Cannabinoid receptors and cholecystokinin in feeding inhibition
Francisco A, et al.
Vitamins and Hormones (2013)
M Bläker et al.
Molecular pharmacology, 58(2), 399-406 (2000-07-25)
Recent efforts have focused on identifying small nonpeptide molecules that can mimic the activity of endogenous peptide hormones. Understanding the molecular basis of ligand-induced receptor activation by these divergent classes of ligands should expedite the process of drug development. Using
Innar Tõru et al.
Psychiatry research, 178(2), 342-347 (2010-05-18)
In this study we examined how personality disposition may affect the response to cholecystokinin tetrapeptide (CCK-4; 50 microg) challenge in healthy volunteers (n=105). Personality traits were assessed with the Swedish universities Scales of Personality (SSP). Statistical methods employed were correlation
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| T6515-100MG | 04061832677989 |
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