T6700
TRAM-34
≥98% (HPLC), Ca2+-activated K+ channel inhibitor, solid
别名:
1- [（2-氯苯基）二苯基甲基]-1H-吡唑
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关于此项目
经验公式（希尔记法）:
C22H17ClN2
化学文摘社编号:
分子量:
344.84
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
TRAM-34, ≥98% (HPLC), solid
SMILES string
Clc1ccccc1C(c2ccccc2)(c3ccccc3)n4cccn4
InChI key
KBFUQFVFYYBHBT-UHFFFAOYSA-N
InChI
1S/C22H17ClN2/c23-21-15-8-7-14-20(21)22(25-17-9-16-24-25,18-10-3-1-4-11-18)19-12-5-2-6-13-19/h1-17H
assay
≥98% (HPLC)
form
solid
color
off-white
solubility
DMSO: 2 mg/mL
H2O: insoluble
storage temp.
2-8°C
Quality Level
Application
TRAM-34 已被用于研究其对预防球囊血管成形术后血管再狭窄的作用。
Biochem/physiol Actions
TRAM-34 对 IK Ca 1 通道的选择性是其他 K + 通道的 100 倍 (K d = 20 nM)（卡律蝎毒素，K d = 5 nM, 克霉唑，K d = 70 nM；尼群地平 K d = 900 nM）。此外，已知 TRAM-34 可抑制人 T 淋巴细胞的活化 。
TRAM-34 是中电导 Ca2+ 激活 K+ 通道的强效抑制剂。
Preparation Note
TRAM-34 可溶于 DMSO (2 mg/mL)。但不溶于水。
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Aquatic Chronic 4
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
H Wulff et al.
Proceedings of the National Academy of Sciences of the United States of America, 97(14), 8151-8156 (2000-07-08)
The antimycotic clotrimazole, a potent inhibitor of the intermediate-conductance calcium-activated K(+) channel, IKCa1, is in clinical trials for the treatment of sickle cell disease and diarrhea and is effective in ameliorating the symptoms of rheumatoid arthritis. However, inhibition of cytochrome
Génesis Vega et al.
JCI insight, 5(16) (2020-08-21)
Airway mucociliary clearance (MCC) is the main mechanism of lung defense keeping airways free of infection and mucus obstruction. Airway surface liquid volume, ciliary beating, and mucus are central for proper MCC and critically regulated by sodium absorption and anion
Friederike A Steudel et al.
Molecular oncology, 11(9), 1172-1188 (2017-05-31)
Oncogenic signalling via Ca
K George Chandy et al.
Trends in pharmacological sciences, 25(5), 280-289 (2004-05-04)
The voltage-gated Kv1.3 channel and the Ca(2+)-activated IKCa1 K(+) channel are expressed in T cells in a distinct pattern that depends on the state of lymphocyte activation and differentiation. The channel phenotype changes during the progression from the resting to
Crocin Improves the Endothelial Function Regulated by Kca3.1 Through ERK and Akt Signaling Pathways.
Huike Yang et al.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 46(2), 765-780 (2018-04-06)
Based on the protective effect of crocin against cardiovascular diseases, we hypothesize that crocin could improve endothelial function through activating the eNOS(endothelial nitric oxide synthase) /NO pathway and/or the intermediate-conductance Ca2+-activated K+ channels (KCa3.1). In this study, rat aortic rings
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