T6700
TRAM-34
≥98% (HPLC), Ca2+-activated K+ channel inhibitor, solid
别名:
1- [（2-氯苯基）二苯基甲基]-1H-吡唑
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关于此项目
经验公式（希尔记法）:
C22H17ClN2
CAS Number:
分子量:
344.84
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
Product Name
TRAM-34, ≥98% (HPLC), solid
质量水平
方案
≥98% (HPLC)
表单
solid
颜色
off-white
溶解性
DMSO: 2 mg/mL
H2O: insoluble
储存温度
2-8°C
SMILES字符串
Clc1ccccc1C(c2ccccc2)(c3ccccc3)n4cccn4
InChI
1S/C22H17ClN2/c23-21-15-8-7-14-20(21)22(25-17-9-16-24-25,18-10-3-1-4-11-18)19-12-5-2-6-13-19/h1-17H
InChI key
KBFUQFVFYYBHBT-UHFFFAOYSA-N
相关类别
应用
TRAM-34 已被用于研究其对预防球囊血管成形术后血管再狭窄的作用。
生化/生理作用
TRAM-34 对 IK Ca 1 通道的选择性是其他 K + 通道的 100 倍 (K d = 20 nM)（卡律蝎毒素，K d = 5 nM, 克霉唑，K d = 70 nM；尼群地平 K d = 900 nM）。此外，已知 TRAM-34 可抑制人 T 淋巴细胞的活化 。
TRAM-34 是中电导 Ca2+ 激活 K+ 通道的强效抑制剂。
制备说明
TRAM-34 可溶于 DMSO (2 mg/mL)。但不溶于水。
警示用语：
Warning
危险声明
危险分类
Acute Tox. 4 Oral - Aquatic Chronic 4
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Zhihua Yu et al.
Frontiers in cellular neuroscience, 11, 319-319 (2017-10-28)
Ischemic stroke is a devastating neurological disease that can initiate a phenotype switch in astrocytes. Reactive astrogliosis is a significant pathological feature of ischemic stroke and is accompanied by changes in gene expression, hypertrophied processes and proliferation. The intermediate-conductance Ca
Friederike A Steudel et al.
Molecular oncology, 11(9), 1172-1188 (2017-05-31)
Oncogenic signalling via Ca
H Wulff et al.
Proceedings of the National Academy of Sciences of the United States of America, 97(14), 8151-8156 (2000-07-08)
The antimycotic clotrimazole, a potent inhibitor of the intermediate-conductance calcium-activated K(+) channel, IKCa1, is in clinical trials for the treatment of sickle cell disease and diarrhea and is effective in ameliorating the symptoms of rheumatoid arthritis. However, inhibition of cytochrome
Hanna Bueno-Levy et al.
Frontiers in pharmacology, 10, 1566-1566 (2020-02-06)
Catecholaminergic polymorphic ventricular tachycardia (CPVT) is an inherited, stressed-provoked ventricular arrhythmia. CPVT is treated by β-adrenergic receptor blockers, Na+ channel inhibitors, sympathetic denervation, or by implanting a defibrillator. We showed recently that blockers of SK4 Ca2+-activated K+ channels depolarize the
Giulia Torriani et al.
Journal of virology, 93(6) (2019-01-11)
Arenaviruses are a large family of emerging enveloped negative-strand RNA viruses that include several causative agents of viral hemorrhagic fevers. For cell entry, human-pathogenic arenaviruses use different cellular receptors and endocytic pathways that converge at the level of acidified late
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