T6700
TRAM-34
≥98% (HPLC), Ca2+-activated K+ channel inhibitor, solid
别名:
1- [（2-氯苯基）二苯基甲基]-1H-吡唑
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关于此项目
经验公式（希尔记法）:
C22H17ClN2
化学文摘社编号:
分子量:
344.84
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
产品名称
TRAM-34, ≥98% (HPLC), solid
质量水平
方案
≥98% (HPLC)
表单
solid
颜色
off-white
溶解性
DMSO: 2 mg/mL
H2O: insoluble
储存温度
2-8°C
SMILES字符串
Clc1ccccc1C(c2ccccc2)(c3ccccc3)n4cccn4
InChI
1S/C22H17ClN2/c23-21-15-8-7-14-20(21)22(25-17-9-16-24-25,18-10-3-1-4-11-18)19-12-5-2-6-13-19/h1-17H
InChI key
KBFUQFVFYYBHBT-UHFFFAOYSA-N
相关类别
应用
TRAM-34 已被用于研究其对预防球囊血管成形术后血管再狭窄的作用。
生化/生理作用
TRAM-34 对 IK Ca 1 通道的选择性是其他 K + 通道的 100 倍 (K d = 20 nM)（卡律蝎毒素，K d = 5 nM, 克霉唑，K d = 70 nM；尼群地平 K d = 900 nM）。此外，已知 TRAM-34 可抑制人 T 淋巴细胞的活化 。
TRAM-34 是中电导 Ca2+ 激活 K+ 通道的强效抑制剂。
制备说明
TRAM-34 可溶于 DMSO (2 mg/mL)。但不溶于水。
警示用语：
Warning
危险声明
危险分类
Acute Tox. 4 Oral - Aquatic Chronic 4
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
Friederike A Steudel et al.
Molecular oncology, 11(9), 1172-1188 (2017-05-31)
Oncogenic signalling via Ca
Génesis Vega et al.
JCI insight, 5(16) (2020-08-21)
Airway mucociliary clearance (MCC) is the main mechanism of lung defense keeping airways free of infection and mucus obstruction. Airway surface liquid volume, ciliary beating, and mucus are central for proper MCC and critically regulated by sodium absorption and anion
H Wulff et al.
Proceedings of the National Academy of Sciences of the United States of America, 97(14), 8151-8156 (2000-07-08)
The antimycotic clotrimazole, a potent inhibitor of the intermediate-conductance calcium-activated K(+) channel, IKCa1, is in clinical trials for the treatment of sickle cell disease and diarrhea and is effective in ameliorating the symptoms of rheumatoid arthritis. However, inhibition of cytochrome
Nicole Glaser et al.
Pediatric diabetes, 18(5), 356-366 (2016-05-14)
Diabetic ketoacidosis (DKA) causes brain injuries in children ranging from subtle to life-threatening. Previous studies suggest that DKA-related brain injury may involve both stimulation of Na-K-Cl cotransport and microglial activation. Other studies implicate the Na-K-Cl cotransporter and the Ca-activated K
C Kondo et al.
Experimental physiology, 103(8), 1101-1122 (2018-05-24)
What is the central question of this study? What are the main [Ca2+ ]i signalling pathways activated by ATP in human synovial fibroblasts? What is the main finding and its importance? In human synovial fibroblasts ATP acts through a linked
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