一般描述
Human Thyroglobulin (Tg) is a 660 kDa, dimeric protein produced by and used entirely within the thyroid gland. Human Thyroglobin is used by the thyroid gland to produce the thyroid hormones thyroxine (T4) and triiodothyryonine. Patients with Hashimoto′s thyroiditis or Graves′ disease, frequently develop antibodies against human Thyroglobulin. Thryoglobulin levels in the blood can be used as a tumor marker for certain kinds of thyroid cancer and in Graves′ disease.
生化/生理作用
Thyroglobulin has been shown to induce expression of platelet activating factor in human peripheral blood mononuclear cells which is found elevated in some patients with thyroid disease.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
监管及禁止进口产品
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Ricardo Adaixo et al.
Nature communications, 13(1), 61-61 (2022-01-12)
The thyroglobulin (TG) protein is essential to thyroid hormone synthesis, plays a vital role in the regulation of metabolism, development and growth and serves as intraglandular iodine storage. Its architecture is conserved among vertebrates. Synthesis of triiodothyronine (T3) and thyroxine
E Resetkova et al.
Regional immunology, 4(4), 204-208 (1992-07-01)
Platelet activating factor (PAF), a phospholipid mediator, has been found to play a role in immune reactions, as well as in many pathophysiological alterations in certain disorders. To determine whether there might be a potential role of PAF in the
Andrew N Hoofnagle et al.
The Journal of clinical endocrinology and metabolism, 98(4), 1343-1352 (2013-03-02)
Serum thyroglobulin (Tg) measurements are central to the management of patients treated for differentiated thyroid carcinoma. For decades, Tg measurements have relied on methods that are subject to interference by commonly found substances in human serum and plasma, such as
Stine L Andersen et al.
European journal of endocrinology, 168(5), 723-731 (2013-02-28)
Placental transport of iodide is required for fetal thyroid hormone production. The sodium iodide symporter (NIS) mediates active iodide transport into the thyroid and the lactating mammary gland and is also present in placenta. NIS is competitively inhibited by thiocyanate
Pengfei Zhang et al.
Nature communications, 13(1), 2298-2298 (2022-04-29)
Evanescent illumination has been widely used to detect single biological macromolecules because it can notably enhance light-analyte interaction. However, the current evanescent single-molecule detection system usually requires specially designed microspheres or nanomaterials. Here we show that single protein detection and
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