所有图片(2)
About This Item
线性分子式:
CH3OC6H4CH=C(CN)2
CAS Number:
分子量:
184.19
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
质量水平
方案
≥98%
表单
solid
效能
>1250 μM IC50 (negative control)
mp
113-116 °C (lit.)
溶解性
chloroform: soluble 50 mg/mL, clear, light yellow
DMSO: soluble
储存温度
2-8°C
SMILES字符串
COc1ccc(cc1)\C=C(/C#N)C#N
InChI
1S/C11H8N2O/c1-14-11-4-2-9(3-5-11)6-10(7-12)8-13/h2-6H,1H3
InChI key
UOHFCPXBKJPCAD-UHFFFAOYSA-N
基因信息
human ... EGFR(1956)
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应用
Tyrphostin 1 has been used to study its effect on the increase of transgene expression in HeLa and NIH3T3 cells.
生化/生理作用
EGFR tyrosine kinase inhibitor.
Tyrphostin 1 is a small molecule inhibitor of epidermal growth factor (EGF) receptor kinase function. This molecule associates with the substrate subsite of the protein tyrosine kinase (PTK) domain. Tyrphostin 1 is also known to block EGF-dependent receptor autophosphorylation,. Furthermore, studies have reported that tyrphostin 1 can block Ca2+ channels and inhibit growth in vascular smooth muscle cells,.
特点和优势
This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
制备说明
Tyrphostin 1 dissolves in chloroform at 50 mg/ml to yield a clear, light yellow solution. It is also soluble in DMSO.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
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