T7068
Thymeleatoxin
99%, solid
方案
99%
表单
solid
颜色
white
溶解性
DMSO: soluble
H2O: insoluble
ethanol: soluble
储存温度
−20°C
InChI
1S/C36H36O10/c1-19(2)34-28(42-25(38)16-15-22-11-7-5-8-12-22)21(4)35-24-17-20(3)27(39)33(24,41)31(40)32(18-37)29(43-32)26(35)30(34)44-36(45-34,46-35)23-13-9-6-10-14-23/h5-17,21,24,26,28-31,37,40-41H,1,18H2,2-4H3/b16-15+/t21-,24-,26+,28-,29+,30-,31-,32+,33-,34+,35-,36?/m1/s1
InChI key
OTTFLYUONKAFGT-WOYWLKGSSA-N
生化/生理作用
Selective activator of PKC isotypes α, β1 and γ
法规信息
新产品
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Bokyung Kim et al.
British journal of pharmacology, 139(2), 408-414 (2003-05-29)
1 Phorbol ester decreases muscle tension in the rat myometrium, and the effect is more potent in late-pregnant myometrium than in nonpregnant myometrium. In the present study, we have examined the contribution of protein kinase C (PKC) isoforms to the
Inês E Baldeiras et al.
Biological research, 39(3), 531-539 (2006-11-16)
Thymeleatoxin (TMX), an activator of Ca2+-sensitive protein kinase C (cPKC) isoforms, was used to assess the PKC isoform specificity of cholinergic potentiation of glucose (11 mM)-induced pulsatile 5-HT/insulin release (PIR) from single mouse pancreatic islets. TMX (100 nM) and carbachol
Grant A Ramm et al.
Digestive diseases and sciences, 48(4), 790-796 (2003-05-14)
Protein kinase C (PKC) may play a role in the intracellular signaling pathways responsible for transforming hepatic stellate cells into myofibroblasts. This study examined the effects of inhibitors and activators of PKC on hepatic stellate cell activation. Stellate cells isolated
M G Kazanietz et al.
Molecular pharmacology, 44(2), 298-307 (1993-08-01)
Analysis of [3H]phorbol-12,13-dibutyrate (PDBu) binding was performed with protein kinase C (PKC)-alpha, -beta 1, -gamma, -delta, -epsilon, -eta, and -zeta produced in Sf9 insect cells using the baculovirus expression system. With the exception of PKC-zeta, all of the PKC isozymes
Jerzy Bełtowski et al.
Acta biochimica Polonica, 51(3), 757-772 (2004-09-28)
We examined the role of protein kinase C (PKC) in the regulation of Na+,K+- ATPase activity in the renal cortex. Male Wistar rats were anaesthetized and the investigated reagents were infused into the abdominal aorta proximally to the renal arteries.
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