T7154
Tyr-Ile-Gly-Ser-Arg
≥97% (HPLC)
别名:
Laminin Fragment 929-933
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关于此项目
经验公式（希尔记法）:
C26H42N8O8
化学文摘社编号:
分子量:
594.66
NACRES:
NA.32
PubChem Substance ID:
UNSPSC Code:
12352209
MDL number:
Form:
powder
Assay:
≥97% (HPLC)
Biological source:
synthetic (organic)
biological source
synthetic (organic)
Quality Segment
assay
≥97% (HPLC)
form
powder
technique(s)
cell culture | mammalian: suitable
solubility
H2O: soluble 1 mg/mL, clear, colorless
storage temp.
−20°C
SMILES string
CC[C@H](C)[C@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O
InChI
1S/C26H42N8O8/c1-3-14(2)21(34-22(38)17(27)11-15-6-8-16(36)9-7-15)24(40)31-12-20(37)32-19(13-35)23(39)33-18(25(41)42)5-4-10-30-26(28)29/h6-9,14,17-19,21,35-36H,3-5,10-13,27H2,1-2H3,(H,31,40)(H,32,37)(H,33,39)(H,34,38)(H,41,42)(H4,28,29,30)/t14-,17-,18-,19-,21-/m0/s1
InChI key
MWOGMBZGFFZBMK-LJZWMIMPSA-N
Application
Tyr-Ile-Gly-Ser-Arg (YIGSR) can be used at the interface between the conjugated polymer and the tissue for the engineering of tissue interface. The product can also be used to study the role of integrins β1, α6, and α3 in promoting type II epithelial differentiation during lung maturation in the fetus.
Biochem/physiol Actions
Tyr-Ile-Gly-Ser-Arg (YIGSR) is a pentapeptide of the protein laminin that reduces the lung colony formation in mice administered with melanoma cells as well as can block the invasiveness of the cells in vitro. It inhibits the increased expression of endothelial nitric-oxide synthase in primary porcine aortic endothelial cells.
Tyr-Ile-Gly-Ser-Arg is a fragment of domain III of the laminin B1 chain . It is a major receptor binding site in laminin. It competes with laminin for the cell surface receptor. It is an inhibitor of tumor growth and metastasis.
Preparation Note
Tyr-Ile-Gly-Ser-Arg dissolves in water at 1 mg/ml to yield a clear, colorless solution.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)