T7329
滔罗林
>97% (NMR), powder
别名:
4,4′-亚甲双[四氢-2H-1,2,4-噻二嗪]1,1,1′,1′-四氧化物, 4,4′-亚甲基双(四氢-1,2,4-磺胺嘧啶 1,1-二氧化物), 牛磺罗定
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关于此项目
经验公式（希尔记法）:
C7H16N4O4S2
化学文摘社编号:
分子量:
284.36
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
243-016-5
MDL number:
InChI
1S/C7H16N4O4S2/c12-16(13)3-1-10(5-8-16)7-11-2-4-17(14,15)9-6-11/h8-9H,1-7H2
InChI key
AJKIRUJIDFJUKJ-UHFFFAOYSA-N
SMILES string
O=S1(=O)CCN(CN1)CN2CCS(=O)(=O)NC2
assay
>97% (NMR)
form
powder
storage condition
protect from light
color
white to off-white
solubility
DMSO: >20 mg/mL
storage temp.
room temp
Quality Level
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Biochem/physiol Actions
滔罗林是一种具有抗肿瘤活性的广谱抗生素，可以引起细胞凋亡并减少肿瘤细胞增殖。
滔罗林是一种具有抗肿瘤活性的广谱抗生素，可以引起细胞凋亡并减少肿瘤细胞增殖。滔罗林已与肿瘤坏死因子相关凋亡诱导配体 (TRAIL) 搭配使用以描述许多细胞凋亡相关信号蛋白的协同反应。由于无毒的滔罗林可以降低重组人肿瘤坏死因子相关凋亡诱导配体 (rhTRAIL) 的毒性和剂量，因此滔罗林与 rhTRAIL 联用的治疗方式可以为癌症治疗提供新的选择。滔罗林也被用作研究细胞凋亡和坏死的多种机理的工具。
Taurolidine is an antibacterial agent that can be used for the treatment of peritonis. It has also been used as an antiendoxic substance for systematic inflammatory response syndrome and as an anti-angiogenic agent for tumors. Furthermore, studies have reported that taurolidine can be used for the prevention of multiple catheter-related bloodstream infections.
Preparation Note
Taurolidine is soluble in DMSO at a concentration that is greater than 20 mg/ml.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Laurie R Solomon et al.
American journal of kidney diseases : the official journal of the National Kidney Foundation, 55(6), 1060-1068 (2010-03-09)
Bacteremia is a major cause of morbidity in patients using intravascular catheters. Interdialytic locking with antibiotics decreases the incidence of bacteremia, but risks antibiotic resistance. Taurolidine is a nontoxic broad-spectrum antimicrobial agent that has not been associated with resistance. Preliminary
Brian Jurewitsch et al.
Clinical nutrition (Edinburgh, Scotland), 24(3), 462-465 (2005-05-18)
The literature shows that repeated courses of antibiotics and catheter removals in a subset of patients suffering from multiple catheter-related bloodstream infections (CRBSI), are unlikely to prevent recurrence. In acceding to preventative strategies, we report our application of the antimicrobial
Suzanne Kats et al.
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 39(4), 451-458 (2010-07-29)
Cardiac surgery with cardiopulmonary bypass provokes a systemic inflammatory response syndrome caused by the surgical trauma itself, blood contact with the non-physiological surfaces of the extracorporeal circuit, endotoxemia, and ischemia. The role of endotoxin in the inflammatory response syndrome has
Sigrun Eick et al.
Clinical oral investigations, 16(3), 735-744 (2011-05-25)
The antimicrobial effect of taurolidine was tested against periodontopathic species in comparison to chlorhexidine digluconate in the presence or absence of serum. Minimal inhibitory concentrations (MIC), microbiocidal concentrations (MBC), as well as killing were determined against 32 different microbial strains
Joseph Lehár et al.
Nature chemical biology, 4(11), 674-681 (2008-10-22)
Predicting the behavior of living organisms is an enormous challenge given their vast complexity. Efforts to model biological systems require large datasets generated by physical binding experiments and perturbation studies. Genetic perturbations have proven important and are greatly facilitated by
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