质量水平
方案
≥90%
储存温度
−20°C
SMILES字符串
NC(=S)C1=CC=C[N](=C1)C2OC(COP(O)(=O)OP(O)(=O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O
InChI
1S/C21H28N7O13P2S/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(40-21)6-38-43(35,36)41-42(33,34)37-5-10-13(29)15(31)20(39-10)27-3-1-2-9(4-27)18(23)44/h1-4,7-8,10-11,13-16,20-21,29-32H,5-6H2,(H2,23,44)(H,33,34)(H,35,36)(H2,22,24,25)
InChI key
JFOSDPGFZXVRDA-UHFFFAOYSA-N
应用
硫代烟酰胺腺嘌呤二核苷酸在 S -腺苷-l-同型半胱氨酸 (AdoHcy) 水解酶 (SAHH) 抑制试验 和 NAD + 糖水解酶活性中被用作底物类似物。
生化/生理作用
硫代烟酰胺腺嘌呤二核苷酸 (sNAD) 是辅酶烟酰胺腺嘌呤二核苷酸 (NAD) 和 NADH 的类似物。NAD+ 激酶调节 NAD+水平，促进癌细胞的细胞毒性。
其他说明
NAD 类似物
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
NAD+ kinase as a therapeutic target in cancer
Tedeschi PM, et al.
Clinical Cancer Research, 22(21), 5189-5195 (2016)
D M Kiick et al.
Biochemistry, 25(1), 227-236 (1986-01-14)
The pH dependence of the kinetic parameters and the primary deuterium isotope effects with nicotinamide adenine dinucleotide (NAD) and also thionicotinamide adenine dinucleotide (thio-NAD) as the nucleotide substrates were determined in order to obtain information about the chemical mechanism and
J R Florini
Analytical biochemistry, 182(2), 399-404 (1989-11-01)
An assay system for creatine kinase using microtiter plates and a plate reader that records absorbancies at 405 nM has been devised. The system is an adaptation of well-established assays that couple creatine kinase with the reactions catalyzed by hexokinase
Suppression of cytosolic NADPH pool by thionicotinamide increases oxidative stress and synergizes with chemotherapy
Tedeschi PM, et al.
Molecular Pharmacology, 88(4), 720?727-720?727 (2015)
Simultaneous determination of multiple forms of lactate dehydrogenase based on NAD and thio-NAD.
S Hosaki et al.
Clinica chimica acta; international journal of clinical chemistry, 157(3), 321-322 (1986-06-30)
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