T7383
丁卡因
≥98% (TLC)
别名:
4-(丁氨基)-苯甲酸-2-(二甲氨基)乙酯
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关于此项目
经验公式（希尔记法）:
C15H24N2O2
化学文摘社编号:
分子量:
264.36
NACRES:
NA.32
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
202-316-6
MDL number:
InChI key
GKCBAIGFKIBETG-UHFFFAOYSA-N
InChI
1S/C15H24N2O2/c1-4-5-10-16-14-8-6-13(7-9-14)15(18)19-12-11-17(2)3/h6-9,16H,4-5,10-12H2,1-3H3
SMILES string
CCCCNc1ccc(cc1)C(=O)OCCN(C)C
biological source
synthetic (organic)
assay
≥98% (TLC)
form
powder
technique(s)
toxicology assay: suitable
storage temp.
2-8°C
Quality Level
Gene Information
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General description
Tetracaine belongs to the amino-ester class and has a pKa of 8.46.
Application
眼用局部麻醉药；用于脊髓麻醉
Tetracaine can be used as a research tool for studying E-C coupling in both skeletal as well as cardiac muscle. The product is a local anaesthetic drug used for studying the impact of numerous drugs on Tumour-necrosis-factor (TNF)-mediated cytotoxicity as well as TNF-induced arachidonic acid release.
Tetracaine has been used as an anesthetic and to lower the glucose synthesis in upper small intestinal infusions. It has also been used to inhibit ryanodine receptors (RyRs) in rats.
Biochem/physiol Actions
阻断 Ca2+ 从肌浆网的电压敏感性释放。
Tetracaine also refers as 4-(Butylamino)benzoic acid 2-(dimethylamino)ethyl ester interfere with calcium movement in muscle and non-muscle cells and can inhibit potassium-induced as well as caffeine-induced shortening of outer hair cells (OHC′s). But, the product can′t inhibit electrically-induced shortening of OHC′s.The product can also stimulate caspase activation and inhibits pro-survival signalling pathways which in turn induce human renal cell apoptosis.
Tetracaine blocks intracellular sodium channels. It mediates phosphorylation of eukaryotic initiation factor 2 (eIF2 α) via translational inhibition of P-body formation.
Preparation Note
250 mg of tetracaine dissolves in 5 ml of EtOH to yield a clear, colorless solution. The product is also soluble in chloroform and ether at a ratio of 1:2 and in ethanol at 1:5. It is very slightly soluble in water.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral - Carc. 2 - Skin Sens. 1
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
法规信息
新产品
此项目有
S Györke et al.
The Journal of physiology, 500 ( Pt 2), 297-309 (1997-04-15)
1. Confocal microfluorometry was used to study the effects of tetracaine on spontaneous Ca2+ release from the sarcoplasmic reticulum (SR) in isolated rat ventricular myocytes. 2. At low concentrations (0.25-1.25 mM), tetracaine caused an initial inhibition of spontaneous release events
H Thomas Lee et al.
American journal of nephrology, 23(3), 129-139 (2003-02-15)
Renal cell apoptosis contributes significantly to the pathogenesis of acute renal failure. Local anesthetics induce apoptosis in neuronal and lymphocytic cell lines. We examined the effects of chronic (48 h) local anesthetic treatment (lidocaine, bupivacaine and tetracaine) on human proximal
Pharmacological considerations for Regional Anesthesia
Principles and Practice of Opthalmic Anesthesia (2018)
Tetracaine, a local anesthetic, preferentially induces translational inhibition with processing body formation rather than phosphorylation of eIF2alpha in yeast
Araki T, et al.
Current Genetics, 61(1), 43-53 (2015)
Insect morphogenetic hormones and developmental mechanisms in the nematode, Nematospiroides dubius.
R D Dennis
Comparative biochemistry and physiology. A, Comparative physiology, 53(1), 53-56 (1976-01-01)
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