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T7455

Tolvaptan

Name: Tolvaptan
Brand: SIGMA

≥98% (HPLC), powder

别名:

N-[4-[(7-Chloro-2,3,4,5-tetrahydro-5-hydroxy-1H-1-benzazepin-1-yl)carbonyl]-3-methylphenyl]-2-methylbenzamide, OPC 41061

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About This Item

经验公式（希尔记法）:

C₂₆H₂₅ClN₂O₃

CAS Number:

150683-30-0

分子量:

448.94

MDL编号:

MFCD09838782

UNSPSC代码:

51111800

PubChem化学物质编号:

329826866

NACRES:

NA.77

质量水平

100

方案

≥98% (HPLC)

表单

powder

颜色

white to tan

溶解性

DMSO: ≥15 mg/mL

创始人

Sanofi Aventis

储存温度

2-8°C

SMILES字符串

Cc1ccccc1C(=O)Nc2ccc(c(C)c2)C(=O)N3CCCC(O)c4cc(Cl)ccc34

InChI

1S/C26H25ClN2O3/c1-16-6-3-4-7-20(16)25(31)28-19-10-11-21(17(2)14-19)26(32)29-13-5-8-24(30)22-15-18(27)9-12-23(22)29/h3-4,6-7,9-12,14-15,24,30H,5,8,13H2,1-2H3,(H,28,31)

InChI key

GYHCTFXIZSNGJT-UHFFFAOYSA-N

基因信息

human ... AVPR2(554)

应用

Tolvaptan has been used as a V2-selective antagonist for studying its effect on hypertension in mice.

生化/生理作用

Tolvaptan (OPC 41061) is a potent, orally active non-peptide vasopressin V2 selective antagonist. IC50 = 3 nM at the rat V2 receptor; 29 times more selective for the V2 than for V1a. Tolvaptan has also been shown to inhibit the development of polycystic kidney disease in several animal models.

Tolvaptan is a potent, orally active non-peptide vasopressin V2 receptor antagonist.

特点和优势

This compound was developed by Sanofi Aventis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

制备说明

Tolvaptan is soluble in DMSO at a concentration that is greater than or equal to 15 mg/ml.

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

0000433893

0000249171

0000224668

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