T7508
丁卡因 盐酸盐
≥99%, Calcium channel blocker
别名:
4-(丁氨基)-苯甲酸-2-(二甲氨基)乙酯, 丁卡因 盐酸盐
产品名称
丁卡因 盐酸盐, ≥99%
质量水平
方案
≥99%
溶解性
chloroform: soluble 30 parts
alcohol: soluble 40 parts
H2O: soluble mg/mL
acetone: insoluble
benzene: insoluble
diethyl ether: insoluble
SMILES字符串
Cl.CCCCNc1ccc(cc1)C(=O)OCCN(C)C
InChI
1S/C15H24N2O2.ClH/c1-4-5-10-16-14-8-6-13(7-9-14)15(18)19-12-11-17(2)3;/h6-9,16H,4-5,10-12H2,1-3H3;1H
InChI key
PPWHTZKZQNXVAE-UHFFFAOYSA-N
基因信息
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相关类别
应用
盐酸丁卡因已用于研究脊髓麻醉的药理作用。盐酸丁卡因也被用作蛋白酶消化缓冲液的组分。
眼用局部麻醉药；用于脊髓麻醉
生化/生理作用
阻断 Ca2+ 从肌浆网的电压敏感性释放。
特点和优势
该化合物在受体分类和信号转导手册的环核苷酸门控（CNG）和超极化激活的环核苷酸门控（HCN）通道页面上有详细描述。想要浏览手册的其他页面， 请单击此处。
该化合物是环核苷酸研究推荐产品。点击此处 ，查看更多环核苷酸精选产品。想要了解有关生物活性小分子在其他研究领域应用的更多信息，请访问 sigma.com/discover-bsm。
制备说明
盐酸丁卡因溶于水，浓度为50 mg/mL，得到无色澄清溶液。它也可溶于40份酒精和30份氯仿。但是，它实际上不溶于醚、苯或丙酮。
警示用语：
Danger
危险声明
危险分类
Acute Tox. 3 Oral - Eye Irrit. 2 - STOT SE 3
靶器官
Central nervous system
储存分类代码
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
L Langerman et al.
Anesthesiology, 74(1), 105-107 (1991-01-01)
A novel approach for increasing the duration of anesthesia after a single subarachnoid injection of a local anesthetic is presented. Tetracaine 1% 0.5 mg/kg was administered in 10% glucose or in lipid solution (iophendylate) in two groups of rabbits via
A M Knight et al.
European journal of immunology, 22(3), 879-882 (1992-03-01)
Recent reports have shown that both exogenous and endogenous mouse mammary tumor viruses (MMTV) can encode superantigens. Transfection and transgenic studies have identified the open reading frame (ORF) present in the 3' long terminal repeat (LTR) as encoding superantigen function.
Helen Giannakopoulos et al.
Journal of the American Dental Association (1939), 143(8), 872-880 (2012-08-03)
The authors evaluated the cardiovascular effects and pharmacokinetics of an intranasal 3 percent tetracaine/0.05 percent oxymetazoline spray developed to provide needle-free anesthesia of maxillary teeth. The authors administered to 12 participants a proposed maximum recommended dose (MRD) (18 milligrams tetracaine/0.3
Yue Jiang et al.
International journal of pharmaceutics, 436(1-2), 806-814 (2012-08-09)
The aggregation behavior of the cationic drug/anionic surfactant vesicles formed by tetracaine hydrochloride (TH) and double-chain surfactant, sodium bis(2-ethylhexyl)sulfosuccinate (AOT), was investigated. By controlling the molar ratio of TH to AOT, a transition from catanionic vesicles to micelles was observed.
Quan Wen et al.
Cornea, 32(2), 179-184 (2012-08-08)
Our recent tissue cross-linking studies have raised the possibility of using aliphatic β-nitroalcohols (BNAs) for pharmacologic, therapeutic corneal cross-linking. The present study was performed to determine the permeability of BNAs and to explore the use of permeability-enhancing agents. Ex vivo
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Cyclic nucleotides like cAMP modulate cell function via PKA activation and ion channels.
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