biological source
rabbit
Quality Segment
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous glycerol solution
species reactivity
rat, mouse, human
technique(s)
western blot: 1:1,000
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
phosphorylation (pSer262)
Gene Information
human ... MAPT(4137)
mouse ... Mapt(17762)
rat ... Mapt(29477)
General description
Tau (τ), also known as MAPT (microtubule associated protein tau) is encoded by the gene mapped on human chromosome 17q21.3. It is highly expressed in neurons but is most prominent in axons.
Immunogen
chemically synthesized phosphopeptide derived from the region of human tau that contains serine262.
Biochem/physiol Actions
Removal of Tau (τ) results in developmental delay and learning disability. It participates in the pathology of Alzheimer′s disease (AD). Tau helps in the assembly and maintenance of microtubule structure. Measurement of phosphorylated tau (P-tau) levels in cerebrospinal fluid (CSF) acts a potential marker for differentiation between AD and dementia with Lewy bodies (DLB).
Physical form
Supplied in 100 μL of Dulbecco′s phosphate buffered saline (without Mg2+ and Ca2+), pH 7.3, with 50% glycerol, 1.0 mg/mL BSA (IgG, protease free) and 0.05% sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
10 - Combustible liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)