T7687
Anti-Tissue Inhibitor of Metalloproteinase-3, First Loop antibody produced in rabbit
~1 mg/mL, buffered aqueous glycerol solution, affinity isolated antibody
别名:
Anti-TIMP-3
产品名称
Anti-Tissue Inhibitor of Metalloproteinase-3, First Loop antibody produced in rabbit, ~1 mg/mL, buffered aqueous glycerol solution, affinity isolated antibody
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous glycerol solution
species reactivity
human
concentration
~1 mg/mL
technique(s)
western blot: 1:1,000 using a whole cell extract from human fibroblasts (M 3303)
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... TIMP3(7078)
Physical form
Solution in phosphate buffered saline, pH 7.4, containing 50% glycerol and 0.05% sodium azide.
Biochem/physiol Actions
By immunoblotting against the reduced protein, the antibody reacts with bands at ~24 kDa and 30 kDa (unglycosylated and glycosylated, respectively). It also reacts with non-reduced TIMP-3.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Immunogen
synthetic peptide corresponding to the first loop of human tissue inhibitor of metalloproteinase-3.
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signalword
Danger
hcodes
Hazard Classifications
Eye Irrit. 2 - Resp. Sens. 1
存储类别
10 - Combustible liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
法规信息
常规特殊物品
此项目有
Z Saihan et al.
Molecular vision, 15, 1218-1230 (2009-06-19)
To determine the phenotypic and biochemical characteristics of the p.E139K missense variant in tissue inhibitor of metalloproteinase 3 (TIMP3) associated with Sorsby fundus dystrophy (SFD). The coding regions and adjacent intronic sequence of TIMP3 were amplified by polymerase chain reaction
Sarah Naessens et al.
Human mutation, 40(5), 539-551 (2019-01-23)
Sorsby fundus dystrophy (SFD) is a macular degeneration caused by mutations in TIMP3, the majority of which introduce a novel cysteine. However, the exact molecular mechanisms underlying SFD remain unknown. We aimed to provide novel insights into the functional consequences
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