T7697
I-OMe-Tyrphostin AG 538
solid
别名:
α-Cyano-(3-methoxy-4-hydroxy-5-iodocinnamoyl)-(3′,4′-dihydroxyphenyl)ketone, I-OMe-AG 538
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选择尺寸
关于此项目
经验公式（希尔记法）:
C17H12INO5
化学文摘社编号:
分子量:
437.19
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352203
MDL number:
产品名称
I-OMe-Tyrphostin AG 538, solid
InChI
1S/C17H12INO5/c1-24-15-6-9(5-12(18)17(15)23)4-11(8-19)16(22)10-2-3-13(20)14(21)7-10/h2-7,20-21,23H,1H3/b11-4+
SMILES string
COc1cc(cc(I)c1O)\C=C(/C#N)C(=O)c2ccc(O)c(O)c2
InChI key
HSRMHXWCTRFVHK-NYYWCZLTSA-N
form
solid
solubility
DMSO: 50 mg/mL
storage temp.
−20°C
Quality Level
Gene Information
human ... IGF1(3479), IGF1R(3480)
Application
I-OMe-Tyrphostin AG 538 has been used as a cell signaling inhibitor in PC-1 cell lines. It has also been used in high throughput screening assays for IGF1R inhibitors.
Biochem/physiol Actions
Insulin growth factor 1 (IGF-1) receptor protein tyrosine kinase inhibitor.
Features and Benefits
This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
Preparation Note
I-OMe-Tyrphostin AG 538 is soluble in DMSO at 50 mg/ml.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
Sara M Garrett et al.
PloS one, 14(11), e0225422-e0225422 (2019-11-26)
Type 2 insulin-like growth factor (IGF-II) levels are increased in fibrosing lung diseases such as idiopathic pulmonary fibrosis (IPF) and scleroderma/systemic sclerosis-associated pulmonary fibrosis (SSc). Our goal was to investigate the contribution of IGF receptors to IGF-II-mediated fibrosis in these
Identification of Novel IGF1R Kinase Inhibitors by Molecular Modeling and High-Throughput Screening.
R Moriev et al.
Acta naturae, 5(2), 90-99 (2013-07-03)
The aim of this study was to identify small molecule compounds that inhibit the kinase activity of the IGF1 receptor and represent novel chemical scaffolds, which can be potentially exploited to develop drug candidates that are superior to the existing
Haifeng Geng et al.
PloS one, 6(12), e29504-e29504 (2012-01-05)
Small molecules have been identified as potential therapeutic agents for lysosomal storage diseases (LSDs), inherited metabolic disorders caused by defects in proteins that result in lysosome dysfunctional. Some small molecules function assisting the folding of mutant misfolded lysosomal enzymes that
Mahsa Hamzeh et al.
The Journal of endocrinology, 209(1), 55-64 (2011-01-12)
Androgens are the primary regulators of epididymal structure and functions. In the classical view of androgen action, binding of androgen to the intracellular androgen receptor (AR) produces the receptor-steroid complex that has high affinity for DNA response elements and regulates
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