T7924
转化生长因子-α 人
≥98% (SDS-PAGE and HPLC), recombinant, expressed in E. coli, powder, suitable for cell culture
别名:
TGF-α
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关于此项目
经验公式（希尔记法）:
C239H348N70O72S6
化学文摘社编号:
分子量:
5546.14
UNSPSC Code:
12352202
NACRES:
NA.77
MDL number:
Biological source:
human
Recombinant:
expressed in E. coli
Assay:
≥98% (SDS-PAGE and HPLC)
Form:
powder
Mol wt:
5.5 kDa
Impurities:
≤1 EU/μg
产品名称
转化生长因子-α 人, TGF-α, recombinant, expressed in E. coli, powder, suitable for cell culture
biological source
human
recombinant
expressed in E. coli
assay
≥98% (SDS-PAGE and HPLC)
form
powder
potency
≤0.2 ng/mL ED50
quality
endotoxin tested
mol wt
5.5 kDa
packaging
pkg of 1 mg, pkg of 5 mg
storage condition
avoid repeated freeze/thaw cycles
technique(s)
cell culture | mammalian: suitable
impurities
≤1 EU/μg
UniProt accession no.
storage temp.
−20°C
Quality Level
General description
The TNFα (tumor necrosis factor α) gene is mapped to human chromosome 6p21.33. TNFα is a member of TNF superfamily.
Application
Transforming Growth Factor-α human has been used:
- to determine the ideal concentration of growth factors to be used in the culture medium that supports sheep preantral follicles
- in human hepatocytes cell culture and keratinocyte cell culture
- to induce morphogenesis in primary mouse organoids
Biochem/physiol Actions
转化生长因子-α (TGF-α) 是一种 5.5kDa 的多肽，其成熟形式含 50 个氨基酸。最初被鉴定为是一种可逆赋予正常非肿瘤细胞（如正常大鼠肾脏成纤维细胞）转化表型的因子。该活性需要转化生长因子-β (TGF-β) 的存在，其通过单独的受体增强 TGF-α 的作用。TGF-α 可由单核细胞、角化细胞以及许多组织和肿瘤合成。无 TGF-α 表达的转基因小鼠除了发现"波状"皮毛外不会出现其他畸形。TGF-α 通过 EGF 受体发挥作用。
The TNFA gene is significantly associated with the regulation of innate and adaptive immune responses. Polymorphism of TNFA gene is known to cause acute motor axonal neuropathy. The cytokine release and gene action is associated with epithelial cells, myeloid cells, endothelial, as well as tumor cells. Tumor cells are known to release TNFA, specifically in response to chemotherapy.
Physical form
Lyophilized from a 0.2 μm filtered buffered solution.
Analysis Note
The biological activity is measured by its ability to stimulate 3H-thymidine incorpation into BALB/c 3T3 cells.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
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