转化生长因子-α 人

The TNFα (tumor necrosis factor α) gene is mapped to human chromosome 6p21.33. TNFα is a member of TNF superfamily.

Transforming Growth Factor-α human has been used:

• to determine the ideal concentration of growth factors to be used in the culture medium that supports sheep preantral follicles
• in human hepatocytes cell culture and keratinocyte cell culture
• to induce morphogenesis in primary mouse organoids

The TNFA gene is significantly associated with the regulation of innate and adaptive immune responses. Polymorphism of TNFA gene is known to cause acute motor axonal neuropathy. The cytokine release and gene action is associated with epithelial cells, myeloid cells, endothelial, as well as tumor cells. Tumor cells are known to release TNFA, specifically in response to chemotherapy.

转化生长因子-α (TGF-α) 是一种 5.5kDa 的多肽，其成熟形式含 50 个氨基酸。最初被鉴定为是一种可逆赋予正常非肿瘤细胞（如正常大鼠肾脏成纤维细胞）转化表型的因子。该活性需要转化生长因子-β (TGF-β) 的存在，其通过单独的受体增强 TGF-α 的作用。TGF-α 可由单核细胞、角化细胞以及许多组织和肿瘤合成。无 TGF-α 表达的转基因小鼠除了发现"波状"皮毛外不会出现其他畸形。TGF-α 通过 EGF 受体发挥作用。

Lyophilized from a 0.2 μm filtered buffered solution.

The biological activity is measured by its ability to stimulate ³H-thymidine incorpation into BALB/c 3T3 cells.