T7951
Tau 蛋白阶梯，6 种亚型
recombinant, expressed in E. coli, ≥90% (SDS-PAGE), buffered aqueous glycerol solution
别名:
Tau 蛋白分子量标准
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关于此项目
Form:
buffered aqueous glycerol solution
Assay:
≥90% (SDS-PAGE)
Biological source:
human
Recombinant:
expressed in E. coli
Mol wt:
36800, 39700, 40000, 42600, 42900, 45900
biological source
human
recombinant
expressed in E. coli
assay
≥90% (SDS-PAGE)
form
buffered aqueous glycerol solution
mol wt
36800, 39700, 40000, 42600, 42900, 45900
composition
dodecyl sulphate sodium salt, 1-5% , glycerine, 20-30% , mercaptoethanol, 10-20%
technique(s)
immunoelectrophoresis: 10-20 μL using recombinant Tau protein marker, western blot: 2-5 μL using recombinant Tau protein marker
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
Quality Level
Gene Information
human ... MAPT(4137)
General description
研究领域：神经科学
Tau基因跨越100 kb，有16个外显子，定位于人17q21染色体。成人大脑中已确定六种选择性剪接变体，变体大小范围为352-441个氨基酸 。 Tau 蛋白是微管相关蛋白（MAP）家族成员。主要在神经元中表达。
Tau基因跨越100 kb，有16个外显子，定位于人17q21染色体。成人大脑中已确定六种选择性剪接变体，变体大小范围为352-441个氨基酸 。 Tau 蛋白是微管相关蛋白（MAP）家族成员。主要在神经元中表达。
Application
Tau蛋白梯（人的6种同工型）用作免疫磁减量（IMR）分析的样品。也用作 Western 印迹的阳性对照。
Biochem/physiol Actions
神经元中，tau 蛋白在维持微管组装和稳定方面起重要作用。它是微管和其他细胞骨架元件或蛋白之间的连接蛋白。在阿尔茨海默′病和各种称为 ‘tau病变′的神经退行性疾病中，可观察到这种蛋白的过度表达。因此，病理性tau蛋白可作为神经退行性过程的潜在生物标记。
Features and Benefits
包含在大肠杆菌中表达的 6 种重组 Tau 蛋白，包括 6 种 Tau 亚型，分子量分别为 45,900、42,600、42,900、39,700、40,000 和 36,800。蛋白质中不存在组氨酸标签。
Packaging
A 50 μL 瓶装 Tau 蛋白 Ladder 含 6 种亚型中每种 0.25μg。
Physical form
溶液溶于 125 mM Tris-HCl，pH 6.8，含 4%SDS、10%2-巯基乙醇、20% 甘油和 0.004% 溴酚蓝。
Preparation Note
密闭。置于良好通风处。上锁保存或放在只有合格或授权人员才能进入的区域。
signalword
Danger
Hazard Classifications
Acute Tox. 3 Dermal - Acute Tox. 4 Oral - Aquatic Chronic 3 - Eye Dam. 1 - Repr. 2 - Skin Irrit. 2 - Skin Sens. 1 - STOT RE 2 Oral
target_organs
Liver,Heart
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
法规信息
常规特殊物品
此项目有
Antibody-mediated clearance of tau in primary mouse microglial cultures requires Fc gamma-receptor binding and functional lysosomes
Andersson C, et al.
Scientific reports, 9(1), 4658-4658 (2019)
Reeteka Sud et al.
Molecular therapy. Nucleic acids, 3, e180-e180 (2014-07-30)
In Alzheimer's disease, progressive supranuclear palsy, and a number of other neurodegenerative diseases, the microtubule associated protein tau aggregates to form intracellular neurofibrillary tangles and glial tangles, abnormal structures that are part of disease pathogenesis. Disorders with aggregated tau are
Emma S Davies et al.
Cellular and molecular life sciences : CMLS, 79(11), 560-560 (2022-10-22)
Alzheimer's disease is a chronic neurodegenerative disease that accounts for up to 80% of all dementias. Characterised by deteriorations of memory and cognitive function, the key neuropathological features are accumulations of β-amyloid and hyperphosphorylated tau, as 'plaques' and 'tangles', respectively.
Analytical performance of reagent for assaying tau protein in human plasma and feasibility study screening neurodegenerative diseases
Yang S, et al.
Scientific reports, 7(1), 9304-9304 (2017)
Nora Lemke et al.
The Journal of biological chemistry, 295(52), 18508-18523 (2020-11-01)
Synapse loss is associated with motor and cognitive decline in multiple neurodegenerative disorders, and the cellular redistribution of tau is related to synaptic impairment in tauopathies, such as Alzheimer's disease and frontotemporal dementia. Here, we examined the cellular distribution of
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