T8024
河鲀毒素
≥98% (HPLC), powder
别名:
Fugu poison, Maculotoxin, TTX, Tarichatoxin
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关于此项目
经验公式（希尔记法）:
C11H17N3O8
化学文摘社编号:
分子量:
319.27
EC Number:
224-458-8
UNSPSC Code:
12352200
PubChem Substance ID:
Beilstein/REAXYS Number:
49176
MDL number:
assay
≥98% (HPLC)
form
powder
color
white
solubility
dilute citrate or acetate buffer: 1 mg/mL (dissolve at pH 4-5. Aqueous solutions, pH 4-5, are stable if stored frozen.), strong acid or alkaline solutions: unstable (destroyed by boiling at pH 2.)
storage temp.
2-8°C
SMILES string
[H][C@]12OC3(O)OC(C4[C@@H](O)NC(=N)NC4([C@@H]1O)[C@@H]3O)[C@@]2(O)CO
InChI
1S/C11H17N3O8/c12-8-13-6(17)2-4-9(19,1-15)5-3(16)10(2,14-8)7(18)11(20,21-4)22-5/h2-7,15-20H,1H2,(H3,12,13,14)/t2?,3-,4?,5+,6-,7+,9+,10?,11?/m1/s1
InChI key
CFMYXEVWODSLAX-IXUBDLNJSA-N
Gene Information
rat ... Scnn1g(24768)
Application
Tetrodotoxin has been used as standard during HPLC-based analysis of biotoxins from P. punctata tentacles whole crude extract (PHY-N). Tetrodotoxin has also been used to study its effects on low-threshold transient (LTT) Ca2+ currents in rat hippocampal interneurons.
Biochem/physiol Actions
Reversible, selective blocker of Na+ channels.
Reversible, selective blocker of Na+ channels; blocks propagation of impulses in excitable membranes. Used to characterize sodium channels in excitable membranes and to study the role of sodium channels in normal physiology and disease.
Preparation Note
Tetrodotoxin is soluble in dilute citrate or acetate buffer at 1 mg/ml (pH 4-5). Aqueous solutions are stable at pH 4-5 if stored frozen. However, tetrodotoxin is unstable in strong acid or alkaline solutions and is destroyed by boiling at pH2.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 1 Oral
存储类别
6.1B - Non-combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
ppe
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
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相关内容
Instructions
Bradley Watmuff et al.
PloS one, 7(2), e31999-e31999 (2012-03-03)
The obvious motor symptoms of Parkinson's disease result from a loss of dopaminergic neurons from the substantia nigra. Embryonic stem cell-derived neural progenitor or precursor cells, adult neurons and fetal midbrain tissue have all been used to replace dying dopaminergic
Rocky Chau et al.
Aquatic toxicology (Amsterdam, Netherlands), 104(1-2), 61-72 (2011-05-06)
The potent neurotoxin tetrodotoxin (TTX) has been identified from taxonomically diverse marine organisms. TTX possesses a unique cage-like structure, however, its biosynthesis has yet to be elucidated. Biosynthetic studies in the TTX-producing newt Taricha torosa, and in bacterial genera, including
D D Fraser et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 11(9), 2812-2820 (1991-09-01)
Interneurons from the CA1 lacunosum-moleculare (L-M) region were isolated by trypsin-hyaluronidase treatment and mechanical trituration of the L-M. Interneurons isolated in this manner were multipolar with several dendritic processes and could be distinguished from CA1 pyramidal neurons. The properties of