河鲀毒素

Name: 河鲀毒素
Brand: SIGMA

≥98% (HPLC), powder

别名:

Fugu poison, Maculotoxin, TTX, Tarichatoxin

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所有图片(1)

About This Item

经验公式（希尔记法）:

C₁₁H₁₇N₃O₈

CAS Number:

4368-28-9

分子量:

319.27

Beilstein:

49176

EC 号:

224-458-8

MDL编号:

MFCD00213719

UNSPSC代码:

12352200

PubChem化学物质编号:

24900493

方案

≥98% (HPLC)

表单

powder

颜色

white

溶解性

dilute citrate or acetate buffer: 1 mg/mL (dissolve at pH 4-5. Aqueous solutions, pH 4-5, are stable if stored frozen.)
strong acid or alkaline solutions: unstable (destroyed by boiling at pH 2.)

储存温度

2-8°C

SMILES字符串

[H][C@]12OC3(O)OC(C4[C@@H](O)NC(=N)NC4([C@@H]1O)[C@@H]3O)[C@@]2(O)CO

InChI

1S/C11H17N3O8/c12-8-13-6(17)2-4-9(19,1-15)5-3(16)10(2,14-8)7(18)11(20,21-4)22-5/h2-7,15-20H,1H2,(H3,12,13,14)/t2?,3-,4?,5+,6-,7+,9+,10?,11?/m1/s1

InChI key

CFMYXEVWODSLAX-IXUBDLNJSA-N

基因信息

rat ... Scnn1g(24768)

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应用

Tetrodotoxin has been used as standard during HPLC-based analysis of biotoxins from P. punctata tentacles whole crude extract (PHY-N). Tetrodotoxin has also been used to study its effects on low-threshold transient (LTT) Ca²⁺ currents in rat hippocampal interneurons.

生化/生理作用

Reversible, selective blocker of Na⁺ channels.

Reversible, selective blocker of Na⁺ channels; blocks propagation of impulses in excitable membranes. Used to characterize sodium channels in excitable membranes and to study the role of sodium channels in normal physiology and disease.

制备说明

Tetrodotoxin is soluble in dilute citrate or acetate buffer at 1 mg/ml (pH 4-5). Aqueous solutions are stable at pH 4-5 if stored frozen. However, tetrodotoxin is unstable in strong acid or alkaline solutions and is destroyed by boiling at pH2.