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T8200

Tofisopam

Name: Tofisopam
Brand: SIGMA

≥98% (HPLC), solid

别名:

7,8-Dimethoxy-1-(3,4-dimethoxyphenyl)-5-ethyl-4-methyl-5H-2,3-benzodiazepine, EGYT 341, Seriel

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关于此项目

经验公式（希尔记法）:

C₂₂H₂₆N₂O₄

化学文摘社编号:

22345-47-7

分子量:

382.45

NACRES:

NA.77

PubChem Substance ID:

24724636

UNSPSC Code:

12352200

EC Number:

244-922-3

MDL number:

MFCD00823171

Assay:

≥98% (HPLC)

Form:

solid

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属性

Quality Segment

100

assay

≥98% (HPLC)

form

solid

drug control

regulated under CDSA - not available from Sigma-Aldrich Canada

color

white

solubility

DMSO: ~14 mg/mL, H₂O: insoluble

SMILES string

CCC1C(C)=NN=C(c2ccc(OC)c(OC)c2)c3cc(OC)c(OC)cc13

InChI

1S/C22H26N2O4/c1-7-15-13(2)23-24-22(14-8-9-18(25-3)19(10-14)26-4)17-12-21(28-6)20(27-5)11-16(15)17/h8-12,15H,7H2,1-6H3

InChI key

RUJBDQSFYCKFAA-UHFFFAOYSA-N

说明

Application

Tofisopam has been used for studying its biochemical mechanisms of actions using drug repositioning strategies.

Biochem/physiol Actions

Studies have reported that tofisopam functions by blocking PDE4 (phosphodiesterase 4). Furthermore, the S-enantiomer of tofisopam is considered ten times more active than R-enantiomer.

Ligand for the GABA_Areceptor benzodiazepine modulatory site.

Preparation Note

Tofisopam is soluble in DMSO at approximately 14 mg/ml. However, it is insoluble in water.

象形图

GHS07,GHS09

警示词

Warning

危险代码

H302,H400

预防性声明

P273 - P301 + P312 + P330

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Acute 1

存储类别

11 - Combustible Solids

怎么回事？

WGK 2

闪点 (F)

Not applicable

闪点 (°C)