T8694
TrkB/Fc Chimera human
>90% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder
登录并加购，请在购物车里查看协议价、货期和发货地。
选择规格
变更视图
关于此项目
Form:
lyophilized powder
Assay:
>90% (SDS-PAGE)
Biological source:
human
Recombinant:
expressed in NSO cells
Mol wt:
120-130 kDa by SDS-PAGE (reducing), calculated mol wt 71 kDa
biological source
human
Quality Segment
recombinant
expressed in NSO cells
assay
>90% (SDS-PAGE)
form
lyophilized powder
potency
0.1-0.4 μg/mL ED50
mol wt
120-130 kDa by SDS-PAGE (reducing), calculated mol wt 71 kDa
packaging
pkg of 100 μg
storage condition
avoid repeated freeze/thaw cycles
technique(s)
western blot: suitable
impurities
endotoxin, tested
UniProt accession no.
storage temp.
−20°C
Gene Information
human ... NTRK2(4915)
Application
Biochem/physiol Actions
TrkB/Fc Chimera human consist of extracellular domain of human TrkB1 fused to histidine-tagged Fc region of human IgG1 by using a polypeptide linker. TrkB belongs to tyrosine kinase receptors family and facilitates the hippocampal development as well as regulating the synaptic plasticity that underlies long-term potentiation and learning. Brain derived neurotrophic factor (BDNF) and Neurotrophin 4 or 5 are preferred ligands for TrkB. Nevertheless it can also bind to NTF3/neurotrophin-3 that is less efficient in activating the receptor but regulates neuron survival through NTRK2.
Binds specifically to mediate neurotrophins BDNF and NT-4/5.
Member of the Trk family tyrosine kinase receptors. Binds specifically to mediate neurotrophins BDNF and NT-4/5.
Physical form
Lyophilized from 0.2 μm filtered solution in phosphate buffered saline.
Preparation Note
Reconstitute to 100 μg/mL in phosphate buffered saline.
Analysis Note
Inhibits BDNF-induced proliferation of TrkB transfected cells, BaF-TrkB-BD.
Other Notes
Extracellular domain of human TrkB fused to the C-terminal histidine-tagged Fc region of human IgG1.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable