T8761
四丁酚醛
nonionic surfactant
别名:
含有甲醛和环氧乙烷的4-（1,1,3,3-四甲基丁基）苯酚聚合物
InChI
1S/C14H22O.C2H6O2.CH2O/c1-13(2,3)10-14(4,5)11-6-8-12(15)9-7-11;3-1-2-4;1-2/h6-9,15H,10H2,1-5H3;3-4H,1-2H2;1H2
SMILES string
[H]C([H])=O.OCCO.CC(C)(C)CC(C)(C)c1ccc(O)cc1
InChI key
GWJOFBXSBDVUMH-UHFFFAOYSA-N
CMC
0.018 mM
transition temp
cloud point 94.3 °C
solubility
water: miscible
Quality Level
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General description
它是烷基芳基聚醚醇类的非离子液体聚合物。 可用作表面活性剂。
Application
四丁酚醛是烷基芳基聚醚醇类的非离子液体聚合物。它可用作表面活性剂以帮助液化过程。 四丁酚醛可用于开发用于药物递送系统的基于非离子表面活性剂的脂质体（niosomes）。四丁酚醛可用于研究其保护巨噬细胞免受内毒素影响的机制。四丁酚醛可用于研究潜在的细胞毒性。
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
10 - Combustible liquids
wgk
WGK 2
flash_point_f
235.4 °F - closed cup
flash_point_c
113 °C - closed cup
ppe
Eyeshields, Gloves, type ABEK (EN14387) respirator filter
Jung-Hua Steven Kuo et al.
Colloids and surfaces. B, Biointerfaces, 64(2), 208-215 (2008-03-14)
Tyloxapol is reported to prevent macrophages from reacting to endotoxin. However, the intracellular responses that tyloxapol induces in macrophages are still not fully explored. Hence, the objective of this study was to evaluate the intracellular events in macrophages treated with
Jung-hua Steven Kuo et al.
Pharmaceutical research, 23(7), 1509-1516 (2006-06-17)
Tyloxapol, a viscous polymer of the alkyl aryl polyether alcohol type, is classified as a nonionic surfactant and is widely used in biomedical applications. Although tyloxapol has been reported to be cytotoxic in various cell lines, there is no published
M Saravanan et al.
Pharmaceutical biology, 49(10), 1074-1081 (2011-05-20)
Ichnocarpus frutescens (L.) R.Br. (Apocynaceae) is used to treat diabetes and hyperlipidemia in folk medicine. The crude methanol extract and fractions of I. frutescens were investigated for antihyperlipidemic effect. Fresh leaves of I. frutescens were extracted with methanol and fractionated
S K Mehta et al.
Colloids and surfaces. B, Biointerfaces, 101, 434-441 (2012-09-27)
The present study delineates the formulation of niosomes from biocompatible surfactant Tyloxapol and their potential as drug delivery system for anti-tuberculosis drugs. Drug loaded niosomes have a size of 150 nm with a loading efficiency of 97.95±0.2, 98.89±0.2 and 99.50±0.2%
Sadaf Matinkhoo et al.
Journal of pharmaceutical sciences, 100(12), 5197-5205 (2011-10-25)
Myoviridae bacteriophages were processed into a dry powder inhalable dosage form using a low-temperature spray-drying process. The phages were incorporated into microparticles consisting of trehalose, leucine, and optionally a third excipient (either a surfactant or casein sodium salt). The particles
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