biological source
Porcine pituitary glands
Quality Segment
form
powder
specific activity
5 IU/mg
packaging
vial of 10 IU
technique(s)
cell culture | mammalian: suitable
shipped in
ambient
storage temp.
2-8°C
Gene Information
human ... TSHR(7253)
pig ... TSH-BETA(397658)
Application
Thyrotropic hormone from porcine pituitary can be used as a NCTC-135 medium supplement for isolating the thyroid cells which in turn is used for studying the impact of retinoids on non-transformed cells like thyrocytes. The product can also be used in cell proliferation experiment for studying the impact of increased IGF binding proteins 1 level on the function and growth of the thyroid gland in transgenic mice.
Biochem/physiol Actions
Thyrotropic hormone also referred to as Thyrotropin or Thyroid stimulating hormone (TSH) belongs to glycoprotein hormone family. The product can enhance vascular endothelial growth factor (VEGF) secretion and angiogenesis in thyroid cancer cell lines. It modifies EGF receptor function in porcine thyroid follicle cells through a cAMP-dependent process and increases the generation of inositol 1,4,5-trisphosphate in human thyroid cells.
Two-chain glycoprotein hormone. The α-chain is not active, biological specificity attributed rather to the β-chain. Activates adenylate cyclase in the thyroid gland, stimulating iodine uptake, thyroxine synthesis and release. Goitrogenic.
Two-chain glycoprotein hormone. The α-chain is not active, biological specificity attributedto the β-chain.
存储类别
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable