biological source
bovine pituitary glands
form
powder
packaging
vial of 100 μg
technique(s)
cell culture | mammalian: suitable
storage temp.
2-8°C
Quality Level
Gene Information
cow ... TSHB(281552)
human ... TSHR(7253)
General description
促甲状腺素/甲状腺刺激激素(TSH)属于糖蛋白激素家族。该糖蛋白是由垂体前叶的促甲状腺细胞分泌的。以游离形式在血液中循环，具有较短的血浆半寿期。
Application
促甲状腺激素（来自牛垂体）已用于：
- 诱导眼眶成纤维细胞的cAMP生成.
- 作为杜氏改良Eagle培养基(DME)H-21:F-12培养基的组分.
- TSH刺激试验，用于检查非甲状腺疾病(NTI)诱导后的甲状腺功能。
- 研究促甲状腺素在小鼠光周期信号信号诱导中的参与。
Biochem/physiol Actions
促甲状腺素/甲状腺刺激激素(TSH)有助于调节甲状腺功能。TSH对儿童的正常认知和神经发育起着至关重要的作用。循环TSH可结合甲状腺中的细胞表面受体。该激素可诱导甲状腺分泌甲状腺球蛋白和甲状腺激素。TSH可促进甲状腺癌患者的碘(131I)摄取。还可增强甲状腺癌细胞系的血管内皮生长因子(VEGF)分泌和血管生成。
双链糖蛋白激素。α-链是不具有活性的，生物特异性是因为β-链。激活甲状腺中的腺苷酸环化酶，刺激碘摄取、甲状腺素合成和释放。致甲状腺肿大。
Analysis Note
含有磷酸盐缓冲盐
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
监管及禁止进口产品
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