T9025
硫利达嗪 盐酸盐
≥99%, D2 dopamine receptor antagonist
别名:
10-[2-（1-甲基-2-哌啶基）乙基]-2-（甲硫基）-10H-吩噻嗪 盐酸盐
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经验公式（希尔记法）:
C21H26N2S2 · HCl
化学文摘社编号:
分子量:
407.04
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
204-992-8
MDL number:
Assay:
≥99%
Quality level:
产品名称
硫利达嗪 盐酸盐, ≥99%
InChI key
NZFNXWQNBYZDAQ-UHFFFAOYSA-N
InChI
1S/C21H26N2S2.ClH/c1-22-13-6-5-7-16(22)12-14-23-18-8-3-4-9-20(18)25-21-11-10-17(24-2)15-19(21)23;/h3-4,8-11,15-16H,5-7,12-14H2,1-2H3;1H
SMILES string
Cl.CSc1ccc2Sc3ccccc3N(CCC4CCCCN4C)c2c1
assay
≥99%
solubility
H2O: soluble 250 mg plus 5 ml of solvent, clear, colorless to faintly yellow
chloroform: soluble
diethyl ether: insoluble
ethanol: soluble
methanol: soluble
Quality Level
Gene Information
human ... DRD2(1813), DRD3(1814), DRD4(1815), HTR2A(3356), HTR2C(3358)
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相关类别
Application
盐酸噻哒嗪已被用作嵌入剂，使用方波伏安法（SWV）技术分析双链DNA（dsDNA）的完整性。盐酸噻哒嗪还被用作抑制人肝微粒体中肝酶细胞色素P4502D6（CYP2D6）的阳性对照。
Biochem/physiol Actions
D2 多巴胺受体拮抗剂； 吩噻嗪类抗精神病药，减少锥体束外副作用； Ca2+ 通道阻滞剂。
Preparation Note
250 mg盐酸硫代哒嗪可溶于5 ml水中，生成透明、无色至微黄色溶液。盐酸噻哒嗪也可溶于甲醇、乙醇和氯仿，但不溶于乙醚。
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
存储类别
11 - Combustible Solids
wgk
WGK 3
ppe
dust mask type N95 (US), Eyeshields, Gloves
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