产品名称
促甲状腺激素 来源于人类脑垂体, lyophilized powder, ≥6.2 IU/mg (immunoassay, non-sterile)
biological source
human pituitary glands
sterility
non-sterile
form
lyophilized powder
specific activity
≥6.2 IU/mg (immunoassay, non-sterile)
storage condition
(Keep container tightly closed in a dry and well-ventilated place)
technique(s)
cell culture | mammalian: suitable
impurities
HIV Antibodies
Antibody to HCV
Antibody to HBV or Presence of HBSAG, tested negative
shipped in
ambient
storage temp.
2-8°C
Quality Level
Gene Information
human ... TSHB(7252), TSHR(7253)
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Application
来自人类垂体的促甲状腺激素已用作胎儿甲状腺类器官培养基补充剂，刺激其成熟。它还用作原代细胞培养的培养基补充剂，进而用于研究雌激素介导的人类甲状腺肿瘤细胞生长刺激的分子机制。
Biochem/physiol Actions
双链糖蛋白激素。α-链是不具有活性的，生物特异性是因为β-链。激活甲状腺中的腺苷酸环化酶，刺激碘摄取、甲状腺素合成和释放。致甲状腺肿大。
本品品可增强甲状腺癌症细胞中血管内皮生长因子（VEGF）的分泌和血管生成。TSH 激活的 TSHR 通过与 Gs 和 Gq G 蛋白的相互作用激活腺苷 3′,5′-环磷酸（cAMP）通路（通过 Gsa）和磷酸肌醇/钙（IP/Ca2+；通过 Gq）第二信使信号通路。在成熟脂肪细胞中，TSH 通过激活细胞外信号调节激酶/p42/p44（ERK1/2）和 c-Jun N-末端激酶（JNK）的蛋白激酶 A（PKA）依赖性磷酸化抑制脂肪酸合成酶（FASN）表达，帮助脂质代谢。
甲状腺激素对儿童的正常认知和神经发育非常重要。促甲状腺激素（TSH）测试主要用于诊断甲状腺功能。
General description
研究领域：细胞信号传导
促甲状腺激素（Thyrotropic hormone）或促甲状腺激素（thyroid stimulating hormone，TSH）属于糖蛋白激素家族。垂体前叶的促甲状腺细胞产生 TSH 并储存在分泌颗粒中。它包含两个非共价连接的亚基（α 和 β）的异二聚体。
促甲状腺激素（Thyrotropic hormone）或促甲状腺激素（thyroid stimulating hormone，TSH）属于糖蛋白激素家族。垂体前叶的促甲状腺细胞产生 TSH 并储存在分泌颗粒中。它包含两个非共价连接的亚基（α 和 β）的异二聚体。
Packaging
包装规格取决于激素
Physical form
含有激素和盐（来自约 0.1 mL 的 0.05 M 磷酸盐缓冲液，pH 7.4）。
存储类别
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
涉药品监管产品
此项目有
D Manole et al.
The Journal of clinical endocrinology and metabolism, 86(3), 1072-1077 (2001-03-10)
Thyroid tumors are about 3 times more frequent in females than in males. Epidemiological studies suggest that the use of estrogens may contribute to the pathogenesis of thyroid tumors. In a very recent study a direct growth stimulatory effect of
Thyroid-stimulating hormone
The pituitary, 163-201 (2017)
Impact of light exposure on thyroid-stimulating hormone results using the Siemens Advia Centaur TSH-3Ultra assay
Armer J, et al.
Annals of Clinical Biochemistry, 54(5), 612-615 (2017)
Thyroid-stimulating hormone and thyroid-stimulating hormone receptor structure-function relationships
Szkudlinski MW, et al.
Physiological Reviews, 82(2), 473-502 (2002)
Zhenghao Wu et al.
Journal for immunotherapy of cancer, 10(1) (2022-02-02)
Hormones are identified as key biological variables in tumor immunity. However, previous researches mainly focused on the immune effect of steroid hormones, while the roles that thyroid-stimulating hormone (TSH) played in the antitumor response were far from clear. The source
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