跳转至内容
Merck
CN

T9283

Anti-Tropomyosin (Sarcomeric) antibody, Mouse monoclonal

clone CH1, purified from hybridoma cell culture

别名:

Monoclonal Anti-Tropomyosin (Sarcomeric) antibody produced in mouse, Anti-C15orf13, Anti-CMD1Y, Anti-CMH3, Anti-HEL-S-265, Anti-HTM-alpha, Anti-LVNC9, Anti-TMSA

登录 查看组织和合同定价。

选择尺寸

关于此项目

UNSPSC Code:
12352203
NACRES:
NA.41
MDL number:
MFCD00149029

主要文件

查看所有文档
技术服务
需要帮助？我们经验丰富的科学家团队随时乐意为您服务。
让我们为您提供帮助
技术服务
需要帮助？我们经验丰富的科学家团队随时乐意为您服务。
让我们为您提供帮助

产品名称

Anti-Tropomyosin (Sarcomeric) antibody, Mouse monoclonal, clone CH1, purified from hybridoma cell culture

biological source

mouse

conjugate

unconjugated

antibody form

purified from hybridoma cell culture

antibody product type

primary antibodies

clone

CH1, monoclonal

contains

15 mM sodium azide

species reactivity

human, chicken, rat

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50 using sections of human tongue
immunohistochemistry (frozen sections): suitable using human and animal tissue sections
immunoprecipitation (IP): suitable
microarray: suitable
western blot: suitable using native preparations

isotype

IgG1

UniProt accession no.

P09493

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Quality Level

200

Gene Information

chicken ... TPM1(396366)
human ... TPM1(7168)
rat ... Tpm1(24851)

相关类别

General description

Tropomyosin 1 (TPM1) is encoded by the gene mapped to human chromosome 15q22.2. The encoded protein belongs to the TPM protein family.

Immunogen

chicken muscle tropomyosin.

Physical form

Physical form: Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Application

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunohistochemistry (1 paper)
Monoclonal Anti-Tropomyosin (sarcomeric) antibody produced in mouse has been used in immunofluorescence and immunohistochemistry.

Biochem/physiol Actions

The antibody recognizes an epitope on skeletal and cardiac tropomyosin. The antibody shows no reaction with denatured protein by immunoblotting. No cross-reactivity has been observed with smooth muscle or non-muscle tropomyosin.
Tropomyosin 1 (TPM1) is a potent tumor suppressor gene. It is expressed at low levels in various types of solid cancers including, oral squamous cell carcinoma (OSCC) and tongue squamous cell carcinoma. Mutation in the gene is associated with the development of hypertrophic cardiomyopathy. The encoded protein is involved in the regulation of actin-myosin interaction in striated muscles. Tropomyosin plays an essential role in Ca2+ -regulated contraction of cardiac muscle.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

未找到合适的产品？  

试试我们的产品选型工具.

存储类别

12 - Non Combustible Liquids

wgk

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

动植物来源生物产品
常规特殊物品
此项目有

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000512419
0000512419
0000442799
0000442799
0000405460

没有发现合适的版本？

如果您需要特殊版本，可通过批号或批次号查找具体证书。

搜索COA

已有该产品？

在文件库中查找您最近购买产品的文档。

访问文档库

Natalie Gude et al.
Circulation research, 99(4), 381-388 (2006-07-15)
Activation of Akt is associated with enhanced cell cycling and cellular proliferation in nonmyocytes, but this effect of nuclear Akt accumulation has not been explored in the context of the myocardium. Cardiac-specific expression of nuclear-targeted Akt (Akt/nuc) in transgenics prolongs
Tropomyosin-1 acts as a potential tumor suppressor in human oral squamous cell carcinoma
Pan H
PLoS ONE, 12, e0168900-e0168900 (2017)
K H Grinnemo et al.
The Journal of thoracic and cardiovascular surgery, 127(5), 1293-1300 (2004-04-30)
It is thought that adult human mesenchymal stem cells do not induce immunoreactivity even to xenografts. We wanted to study whether adult human mesenchymal stem cells survive and engraft in experimentally induced ischemic rat myocardium. Bone marrow-derived adult human mesenchymal
Myofibril Degeneration Caused by Tropomodulin Overexpression Leads to Dilated Cardiomyopathy in Juvenile Mice
Sussman MA
The Journal of Clinical Investigation, 101, 51-61 (1998)
Effect of Cardiomyopathic Mutations in Tropomyosin on Calcium Regulation of the Actin-Myosin Interaction in Skeletal Muscle.
Kopylova GV
Bulletin of experimental biology and medicine, 162, 42-44 (2016)
查看所有相关文献

相关内容

我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系客户支持