Anti-phospho-TrkA (pTyr⁴⁹⁰) antibody produced in rabbit

TrkA belongs to the Trk proto-oncogene family and is expressed mainly in central and peripheral nervous systems. When TrkA binds to NGF, it autophosphorylates tyrosine residues like-Tyr⁴⁹⁰, Tyr⁶⁷⁴, Tyr⁶⁷⁵, Tyr⁷⁵¹, and Tyr⁷⁸⁵ and subsequently activates many downstream effector proteins. Defects in TrkA lead to congenital insensitivity to pain with anhidrosis. Anti-phospho-TrkA (pTyr⁴⁹⁰) antibody can be used in immunocytochemistry (1:100, using cultured cells). It is also useful in identifying endogenous levels of phosphorylated Tyr⁴⁹⁰ in TrkA, TrkB and TrkC. Rabbit anti- phospho-TrkA (pTyr⁴⁹⁰) antibody is reactive in mouse, human and rat.

synthetic phosphopeptide Tyr⁴⁹⁰ corresponding to residues surrounding Tyr⁴⁹⁰ of human TrkA, conjugated to KLH. This sequence is highly conserved in TrkB and TrkC.

Anti-phospho-TrkA (pTyr⁴⁹⁰) antibody can be used in immunoprecipitation, immunoblotting and immunohistochemistry. It may also be used in western blotting when diluted to ratio of 1:1000 for NGF-treated PC12 cells.

Solution in 10 mM sodium HEPES, pH 7.5, and 150 mM sodium chloride containing 100 μg/ml bovine serum albumin and 50% glycerol.

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